| 奥美拉唑肠溶微丸的制备及其处方优化 |
| |
| 引用本文： | 胡海洋,宋华先,陈大为,葛月宾,马燕. 奥美拉唑肠溶微丸的制备及其处方优化[J]. 中国药学杂志, 2003, 38(10): 780-781 |
| |
| 作者姓名： | 胡海洋 宋华先 陈大为 葛月宾 马燕 |
| |
| 作者单位： | 沈阳药科大学药学院,辽宁,沈阳,110016 |
| |
| 摘 要： | 目的研制奥美拉唑肠溶微丸。方法采用挤出滚圆工艺及流化床包衣法制备了奥美拉唑肠溶微丸，并采用正交试验设计对处方进行了优化。结果所制得的微丸剂在人工胃液中耐酸力良好，在人工肠液中的溶出迅速而且完全。结论有效地解决了奥美拉唑的稳定性问题，而且制备工艺简单易行，重现性好，值得进一步的工业化生产。
|
| 关 键 词： | 奥美拉唑 肠溶微丸 挤出滚圆法 流化包衣 正交试验法 |
| 文章编号： | 1001-2494(2003)10-0780-02 |
| 收稿时间： | 2003-01-02; |
| 修稿时间： | 2003-01-02 |
Preparation and optimization of the formulation of enteric coated omeprazole pellets |
| |
| HU Hai-yang,SONG Hua-xian,CHEN Da-wei,GE Yue-bin,MA Yan. Preparation and optimization of the formulation of enteric coated omeprazole pellets[J]. Chinese Pharmaceutical Journal, 2003, 38(10): 780-781 |
| |
| Authors: | HU Hai-yang SONG Hua-xian CHEN Da-wei GE Yue-bin MA Yan |
| |
| Affiliation: | School of Pharmacy,Shenyang Pharmaceutical University,Shenyang 110016,China |
| |
| Abstract: | OBJECTIVE To develop the enteric coated omeprazole pellets.METHODS The enteric coated omeprazole pellets were prepared with extrusion-spheronization and air-flow coating method and the formulation was optimized by orthogonal design.RESULTS The resistance to acid was good and the dissolution of the pellets was quick in artificial intestinal liquid.CONCLUSION The problem of omeprazole's stability was resolved effectively and the preparation process was simple,feasible and replicable.It is worth further development and application in industry. |
| |
| Keywords: | omeprazole enteric coated pellets extrusion-spheronization air-flow coating method orthogonal design. |
| 本文献已被 CNKI 维普 万方数据 等数据库收录！ |
| 点击此处可从《中国药学杂志》浏览原始摘要信息 |
|
点击此处可从《中国药学杂志》下载免费的PDF全文 |
