女性原发性骨质疏松症危险因素研究

目的探索女性原发性骨质疏松症(Primary Osteoporosis,POP)的危险因素,为制定群体综合防治POP对策提供依据。方法共纳入研究对象413例;采用问卷调查收集研究对象人口学特征及POP危险因素的信息;运用双能X骨密度测量仪(DEXA)测定骨密度值,并进行POP诊断;使用χ2检验、Logistic回归分析POP的危险因素。结果随绝经年限增加,POP发生率增加,χ2检验差异具有统计学意义。单因素分析结果显示年龄、初潮年龄、月经状态、BMI、补钙情况、吸烟情况与POP患病的关系有统计学意义;多因素分析结果表明,在控制了其他因素后,年龄和吸烟情况与POP患病的关系有统计学意义。结论年龄增加、绝经年限增加、吸烟是患POP的危险因素。

A Cross-sectional Study on the Risk Factors of Women' Primary Osteoporosis

Objective To explore the risk factors of primary osteoporosis（POP）among women and provide evidence for establishing population based strategy to prevent and treat POP.Methods A total of 413 women were recruited in the study to receive the questionnaire survey to know their demographical characteristics and risk factors of POP.Their mineral densities were measured by the dual energy X-ray absorption（DEXA）to determine whether they suffered from POP or not.Then the data were analyzed by χ^2test and logistic regression.Results The incidence of POP increased with the menopausal years,the difference had the statistical significance.Monofactorial analysis showed that age,menarche age,menstrual status,body mass index,calcium supplementation and smoking were significantly associated with POP.Moreover,multifactorial analysis indicated that age and smoking were still significantly associated with POP by adjusting another risk factors.Conclusion Increasing of age,longer menopausal years and smoking were the risk factors of POP.