痹肿消汤对类风湿性关节炎患者T细胞亚群的影响

目的：研究痹肿消汤（BZX）对类风湿性关节炎（RA）患者外周血淋巴T细胞亚群的影响，从细胞免疫探讨本方药的疗效机制。方法：选择RA活动期患者42例，随机分为BZX治疗组和西药（TMX与普威）治疗对照组；20名健康人为正常对照组，于治疗前和治疗3月后分别检测CD4^ ,CD8^ ，计算CD4^ /CD8^ 。结果：治疗前RA患者外周血CD4^ 较正常人对照组增高（P＜0．01），CD8^ 较正常人对照组降低（P＜0．01），CD4^ /CD8^ 值较正常人对照组升高（P＜0．01），治疗3月后，治疗两组CD4^ 下降，CD8^ 升高，CD4^ /CD8^ 值降低，均接近于正常；两组各指标比较差异无显著性（P＞0．05）。结论：RA患者体内存在着细胞免疫调节紊乱，痹肿消汤能调节T细胞分布紊乱，有助于机体恢复免疫稳定状态，具有类似MTX联合用药的免疫抑制效应。

The effects of bizhongxiao decotion (BZX) on T-lymphocyte subsets in the peripheral blood of patients with rheumatoid arthritis]

OBJECTIVE: To observe the effect of BZX on T-lymphocyte subsets in the peripheral blood of patients with rheumatoid arthritis (RA) and study the mechanism of curative effects of BZX in immunization. METHODS: 42 patients with RA in active stage were divided into 1. treatment group with BZX 2. control group with western medicine and twenty healthy control group (HCG) was arranged before treatment. Their CD4+ and CD8+ were tested and the ratio of CD4+ cells to CD8+ cells was calculated before treatment and after 3 months treatment. RESULTS: In the peripheral blood of patients with RA, CD4+ was more than that of the HCG. but CD8+ was lower and the ratio of CD4+ cell to CD8+ cells was higher than that of the HCG. After 3 months treatment, CD4+ decreased, CD8+ increased and the ratio of CD4+ cells to CD8+ cells decreased. In addition, all results were similar to the normal. We found there were no significant differences between the two treatment groups in the results after treatment. CONCLUSION: There were cell immunoregulation disorders in patients with RA. BZX can regulate the disorder of T-lymphocyte subsets, help rebuild the immune steading and have effects of immune suppression similar to MTX combined medicine.