| 调血脂药阿托伐他汀钙的合成研究进展 |
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| 引用本文： | 张宜凡,虞心红.调血脂药阿托伐他汀钙的合成研究进展[J].中国药业,2010,19(21):4-6. |
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| 作者姓名： | 张宜凡 虞心红 |
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| 作者单位： | 1. 上海医药高等专科学校药学系,上海,201318
2. 华东理工大学药学院,上海,200137 |
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| 摘 要： | 综述治疗高脂血症的他汀类药物阿托伐他汀钙的合成方法,根据文献报道归纳出阿托伐他汀钙的合成路线有两种,一种是先合成出取代的吡咯环,然后在环上引入手性的3,5-顺式双羟基庚酸结构（线性合成）,一种是先制备手性的3,5-顺式二羟基庚酸片断,然后与1,4-二羰基化合物环合得到吡咯环结构（汇聚合成）。还比较了各合成工艺方法的优缺点,为寻找一条适合大规模、工业化生产的工艺路线提供参考。
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| 关 键 词： | 调血脂药 阿托伐他汀钙 合成 |
Study on Synthetic Routes of Atorvastatin Calcium of Hypolipidemic Drugs |
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| Zhang Yifan,Yu Xinhong.Study on Synthetic Routes of Atorvastatin Calcium of Hypolipidemic Drugs[J].China Pharmaceuticals,2010,19(21):4-6. |
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| Authors: | Zhang Yifan Yu Xinhong |
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| Institution: | Zhang Yifan1,Yu Xinhong2(1.Department of Pharmacy,Shanghai Institute of Health Science,Shanghai,China 201318,2.Institute of Pharmacy,East China University of Science and Technology,China 200137) |
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| Abstract: | This review summarized the various synthetic processes of atorvastatin calcium.There are two ways of synthesis of atorvastatin calcium based on the references.One is to synthesize the substitued pyrrole ring firstly,the introduct chiral 3,5-cis-dihydroxy heptanoic acid structure into the ring(linear synthesis).The other one is to prepare chiral 3,5-cis-dihydroxy heptanoic acid fragment,the form the pyrrole ring structure with 1,4-dicarbonyl compounds(pool synthesis).By comparison of the merits and demerits ... |
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| Keywords: | hypolipidemic drugs atorvastatin calcium synthetic routes |
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