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Plasma lipids, lipoproteins and apoproteins in a case of apo C-II deficiency |
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| Authors: | Alberico L. Catapano Gervase L. Mills P. Roma Mario La Rosa Antonio Capurso |
| Affiliation: | a Institute of Pharmacology and Pharmacognosy, University of, Milan, Italy b Courtauld Institute of Biochemistry, London, UK c University of Catania, Section of Pediatrics, Italy d University of Bari, 2nd Medical Clinic, Italy |
| Abstract: | A new case of apo C-II deficiency is described. The patient had plasma triglyceride levels ranging from 10.2–30.5 mmol/1. Apo C-II deficiency was confirmed by gel electrophoresis, isoelectric focusing and immunochemistry. In this patient plasma lipoproteins were mainly chylomicrons and very low density lipoproteins, LDL and HDL levels being very low. Infusion of normal plasma effectively reduced plasma triglycerides and enhanced low density and high density lipoproteins cholesterol levels. These data suggest that in vivo a precursorproduct relationship exists between triglyceride rich lipoproteins and LDL and HDL, and further stress the role of the lipoprotein lipase-apo C-II system in modulating these metabolic interconversions. |
| Keywords: | Correspondence should be addressed to Dr. A.L. Catapano Institute of Pharmacology and Pharmacognosy. University of Milan Via Andrea del Sarto 21 20129 Milan Italy. |
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