| HPLC法测定复方丹参渗透泵型控释片中丹参酮ⅡA的含量 |
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| 引用本文： | 苏丹,胡容峰,杨敏,赵红,朱金燕. HPLC法测定复方丹参渗透泵型控释片中丹参酮ⅡA的含量[J]. 亚太传统医药, 2008, 4(2): 42-44 |
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| 作者姓名： | 苏丹 胡容峰 杨敏 赵红 朱金燕 |
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| 作者单位： | 1. 安徽中医学院药学院,安徽,合肥,230031
2. 安徽中医学院药学院,安徽,合肥,230031;安徽省中药研究与开发重点实验室,安徽,合肥,230038 |
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| 摘 要： | 目的:建立以HPLC法测定复方丹参渗透泵型控释片中丹参酮ⅡA的含量的方法。方法:色谱柱为Hy-persil ODS C18柱(4.6mm×250mm,5μm),流动相为甲醇:水(85:15);流速为1.0mL.min-1;检测波长为270nm。结果:丹参酮IIA在1.6～14.4μg.mL-1浓度范围之间线性良好,r=0.9998;平均回收率为98.41%,RSD=1.64%。结论:本法准确、灵敏、重现性好、操作简便,主峰与杂质峰分离完全,可用于复方丹参渗透泵型控释片的质量控制。
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| 关 键 词： | 高效液相色谱法 复方丹参 渗透泵片 丹参酮ⅡA |
| 文章编号： | 1673-2197（2008）02-042-03 |
| 收稿时间： | 2007-12-21 |
Determination of Tanshinone ⅡA in Compound Danshen Osmotic Pump Controlled Release Tablets by HPLC |
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| Su Dan,Hu Rongfeng,Yang Min,Zhao Hong,Zhu Jinyan. Determination of Tanshinone ⅡA in Compound Danshen Osmotic Pump Controlled Release Tablets by HPLC[J]. Asia-Pacific Traditional Medicine, 2008, 4(2): 42-44 |
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| Authors: | Su Dan Hu Rongfeng Yang Min Zhao Hong Zhu Jinyan |
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| Affiliation: | Su Dan, Hu Rongfeng, Yang Min, Zhao Hong, Zhu Jinyan (1. Anhui College of Traditional Chinese Medicine,College of Pharmacy; Hefei, Anhui 230038, China;2. Anhui Province Key Laboratory of R ＆ D of Chinese Medicine,Hefei, Anhui, 230038,China) |
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| Abstract: | Objective. To develop a HPLC method for the determination of Tanshinone Ⅱ A in Compound Danshen osmotic pump controlled release tablets. Methods： Chromatography was carried out on a Hypersil ODS C18（4. 6mm× 250mm, 5μm）, using a mobile phase of alcohol-water（85：15） with a flow rate at 1.0 mL·min^-1. The UV detective wavelength was 270 ran. Results. With-in 1.6-14. 4μg·mL^-1 Tanshinone Ⅱ A had a good linearity （r=0.9998）, the average recovery was 98. 41% with RSD of 1.64 %. Conclusion： The method is accurate, sensible, reproducible, simple and can be used in the quality control of Compound Dan-shen osmotic pump controlled release tablets. |
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| Keywords: | HPLC Compound Danshen Osmotic pump controlled release tablets Tanshinone Ⅱ A |
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