| PTTG蛋白和c-myc蛋白在原发性肝细胞癌中的表达 |
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| 引用本文： | 金中元,郑长黎,郑晖. PTTG蛋白和c-myc蛋白在原发性肝细胞癌中的表达[J]. 中国现代医学杂志, 2002, 12(17): 11-13 |
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| 作者姓名： | 金中元 郑长黎 郑晖 |
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| 作者单位： | 中南大学湘雅医学院病理学教研室,长沙,410078 |
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| 摘 要： | 目的 :研究PTTG蛋白和c -myc蛋白与原发性肝细胞癌 (HCC)发生的关系。方法 :应用免疫组织化学方法 (SP法 )检测 6 1例人肝细胞癌和癌旁肝组织中PTTG蛋白和c -myc蛋白的表达。结果 :PTTG蛋白和c-myc蛋白在肝癌中阳性率分别为 78.7% (48/ 6 1)和 6 7.2 % (41/ 6 1) ,在癌旁组织中阳性率分别为 91.8%(5 6 / 6 1)和 83.6 % (5 1/ 6 1) ,相关性研究显示PTTG蛋白和c -myc蛋白表达关系密切 (P <0 .0 0 5 )。结论 :PTTG和c-myc蛋白过度表达参与了人肝细胞癌的发生发展过程。
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| 关 键 词： | 肝细胞瘤 癌基因 癌基因产物 免疫组化 |
| 修稿时间： | 2002-05-10 |
EXPRESSION OF PTTG PROTEIN AND C-MYC PROTEIN IN PRIMARY HUMAN HEPATOCELLULAR CARCINOMA |
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| Jin Zhongyuan,Zheng Changli,Zheng Hui. EXPRESSION OF PTTG PROTEIN AND C-MYC PROTEIN IN PRIMARY HUMAN HEPATOCELLULAR CARCINOMA[J]. China Journal of Modern Medicine, 2002, 12(17): 11-13 |
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| Authors: | Jin Zhongyuan Zheng Changli Zheng Hui |
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| Affiliation: | Jin Zhongyuan,Zheng Changli,Zheng Hui Department of Pathology,Xiangya School of Medicine,Central South University,Changsha 410078$$$$ |
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| Abstract: | Objective:In order to investigate the relationship between the expression of PTTG protein and that of c-myc protein and their role in oncogenesis of primary human hepatocellularcarcmomas(HCC). Methods:Immunohistochemistry (SP method) was used to detect the expressions of PTTG protein and c-myc protein in 61 cases of human hepatocellular carcinomas.Results:The positive rates of PTTG protein and c-myc protein were 78.7% (48/61) and 67.2% (41/61) in HCC , and 91.8% (56/61) and 83.6% (51/61) in pericarcinomatous liver tissue. The expression of PTTG protein was significantly correlated with that of c-myc protein (P<0.005).Conclusion:Overexpression of PTTG and c-myc proteins may be related to human hepatocellular carcinogenesis. |
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| Keywords: | Hepatoma Oncogene Oncogene Products Immunohistochemistry |
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