| 新疆一枝蒿乙酸乙酯部位化学成分研究 |
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| 引用本文： | 崔凤侠,章宸,姜勇,屠鹏飞.新疆一枝蒿乙酸乙酯部位化学成分研究[J].中国中药杂志,2013,38(11):1757-1759. |
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| 作者姓名： | 崔凤侠 章宸 姜勇 屠鹏飞 |
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| 作者单位： | 1. 北京大学药学院天然药物及仿生药物国家重点实验室,北京100191;承德医学院河北省中药研究与开发重点实验室,河北承德067000
2. 北京大学药学院天然药物及仿生药物国家重点实验室,北京,100191 |
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| 基金项目： | 国家自然科学基金项目(30973629);国家"重大新药创制"科技重大专项 (2012ZX09301002-002-002,2012ZX09304-005) |
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| 摘 要： | 研究新疆一枝蒿Artemisia rupestris全草的化学成分.采用硅胶、反相、凝胶等柱色谱分离技术,对新疆一枝蒿乙酸乙酯部位进行分离纯化,采用波谱技术分析和理化常数对照等方法进行结构鉴定.从新疆一枝蒿乙酸乙酯部位分离并鉴定了12个化合物,分别为5,4'-二羟基-3,6,7-三甲氧基黄酮(1)、R-(-)-vestitol(2)、小麦黄素(3)、金圣草黄素(4)、3-吲哚甲酸(5)、七叶内酯(6)、芹菜素(7)、木犀草素(8)、反式咖啡酸(9)、紫花牡荆素(10)、金腰乙素(11)和洋艾素(12).化合物2为首次从蒿属植物分离得到,化合物1～6,9为首次从本植物中分离得到.
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| 关 键 词： | 菊科 新疆一枝蒿 化学成分 |
| 收稿时间： | 2/4/2013 12:00:00 AM |
Chemical constituents from ethyl acetate extract of Artemisia rupestris |
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| CUI Feng-xi,ZHANG Chen,JIANG Yong and TU Peng-fei.Chemical constituents from ethyl acetate extract of Artemisia rupestris[J].China Journal of Chinese Materia Medica,2013,38(11):1757-1759. |
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| Authors: | CUI Feng-xi ZHANG Chen JIANG Yong and TU Peng-fei |
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| Institution: | State Key Laboratory of Natural and Biomimetic Drugs, School of Pharmaceutical Sciences, Peking University, Beijing 100191, China;Key Laboratory of Traditional Chinese Reserch and Development in Heibei Province, Chengde Medical University, Chengde 067000, China;State Key Laboratory of Natural and Biomimetic Drugs, School of Pharmaceutical Sciences, Peking University, Beijing 100191, China;State Key Laboratory of Natural and Biomimetic Drugs, School of Pharmaceutical Sciences, Peking University, Beijing 100191, China;State Key Laboratory of Natural and Biomimetic Drugs, School of Pharmaceutical Sciences, Peking University, Beijing 100191, China |
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| Abstract: | Chemical constituents of ethyl acetate extract of Artemisia rupestris were isolated and purified by various chromatographic methods, including silica gel, ODS and Sephadex LH-20. Their structures were elucidated on the basis of spectroscopic data analysis. 12 compounds were separated from A. rupestris and their structures were identified as 5,4'-dihydroxy -3,6,7-trimethoxy flavone (1), R-(-)-vestitol (2), tricin (3), chrysoeriol (4), 3-indole carboxylic acid (5), esculetin (6), apigenin (7), luteolin (8), trans-caffeic acid (9), casticin (10), chrysosptertin B (11) and artemetin (12). Compound 2 was obtained from the genus Artemisia for the first time, and compounds 1-6 and9were separated from this plant for the first time. |
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| Keywords: | Compositae Artemisia rupestris chemical constituents |
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