三联药物背肌注射治疗支气管哮喘急性发作临床研究--附600例病例报告

目的:探讨选择背部肌肉注射药物治疗支气管哮喘急性发作的治疗效果,皆在寻求一种方便、快捷、高效、安全的平喘治疗途径.方法:将确诊为支气管哮喘急性发作的963例患者中资料完整的600例随机分为A、B、C 3组.A组:在患者的背部注射本院配制的三联药物(决明茶碱,薯芋皂甙,莨菪碱);B组:常规肌肉注射上述三联药物;C组:质量分数为5%的葡萄糖20 ml 氨茶碱0.25 g 地塞米松10 mg静脉注射.治疗前及治疗20 min后3组均行肺功能测定,治疗20 min后评价疗效.结果:A组:显效时间1～10 min,明显改善率为49.0%,中度改善率为37.5%,轻度改善率为12.0%,无改善率为1.5%;B组:显效时间30～45 min,明显改善率为14.0%,中度改善率为11.5%,轻度改善率为42.5%,无改善率为32.0%;C组:显效时间5～15 min,明显改善率为46.0% ,中度改善率为36.5%,轻度改善率为13.0%,无改善率为4.5%;A、B两组疗效有显著性差异(P<0.01),A、C两组间无显著性差异(P>0.05).A组和C组治疗后用力肺活量(FVC)、第1秒呼出气量(FEV1)、呼气中段流量(MMEF)3项肺功能指标改善明显,B组治疗后无明显改善.结论:背肌注射药物方便易行、快捷、高效、安全,疗效可靠,同时避免了静脉用氨茶碱及激素带来的不良反应,临床值得推广.

Clinical study on remedy for acute paroxysmal bronchial asthma by injecting three medicines in dorsal muscle:report of 600 cases

Objective: To investigate the curative effect of remedy for acute paroxysmal bronchial asthma by dorsal muscle injection in order to seek a convenient, high effectual and safe treatment for acute paroxysmal bronchial asthma. Methods: Six hundred patients with acute paroxysmal bronchial asthma were randomly divided into three groups. Three selfcompound medicines were injected in dorsal muscle in group A and were injected conventional intramuscularly in group B, and 5% glucose 20 ml aminophylline 0 25 g dexamethasone 10 mg were injected intravenously in group C. The lung function was measured before and 20 minutes after treatment for each group. The curative effect was estimated 20 minutes after treatment. Results: In group A, marked effect time was 1 to 10 minutes, 49 0% of the patients were improved markedly, 37 5% were improved middling, 12 0% were improved lowgrade and 1 5% was no effect. In group B, marked effect time was 30 to 45 minutes, 14 0% of the patients were improved markedly, 11 5% were improved middling, 42 5% were improved lowgrade and 32 0% were no effect. In group C, marked effect time was 5 to 15 minutes, 46 0% of the patients were improved markedly, 36 5% were improved middling, 13 0% were improved lowgrade and 4 5% were no effect. Group A and group C appeared significant effect after treating, and group B was no any improvement after treating. The curative effect between group A and group B was significantly different(P<0 05). There was no significant difference between group A and group C(P>0 05). Forced vital capacity(FVC), forced expiratory volume in one second(FEV1), and maximal midexpiratory flow(MMEF) were significantly different before treatment compared to those after treatment in group A and C, but no significant improvement in group B. Conclusion: The treatment of injecting medicine in dorsal muscle is a convenient, high effectual, safe remedy for acute paroxysmal bronchial asthma. And it can prevent from the side effect of injecting aminophylline and hormone.