涎腺含肌上皮细胞性肿瘤分化及起源之初探

目的 为了进一步探讨含肌上皮细胞性肿瘤的分化与起源，以及提高鉴别诊断水平。方法 应用免疫组织化学对涎腺肌上皮瘤和多乳形腺瘤的ＣＫ－１８，Ａｃｔｉｎ表达以及组织学特征进行研究。结果 人组织结构上看，肌上皮瘤由肿瘤性肌上皮细胞为主“主质成分”和腺管产结构为辅的“次质成分”构成；多形性腺瘤则由粘液和软骨样物质组成的“细胞疏松区”和上皮性与肌上皮性两种成分组成的“细胞密集区”构成。从免疫组织化学表达上看，

Investigation on the differentiation and origination of the tumor comprised neoplastic myoepithalial cells from salivary glands

Objective To probe into the differentiation and histogenesis of the tumors contained neoplastic myoepithalial cells from salivary glands and to improve the diagnosis of myoepithelioma. Methods The immunohistochemical expression of CK18,Actin and the histological characteristics of the tumors were observed. Results Myoepithelioma was comprised of predominant neophlastic myoepithalial cells and few adenoidal structure.Pleomorphic adenoma was made up of loose cellular district and concentrated cellular district.There were mostly mucoid and chondroid substance in the loose cellular district but epithelial and myoepithalial cells in the concentrated cellular district.CK18 and Actin expressed in the duct cells but the both not expressed in the alveoli cells.CK18 and Actin expressed in the myoepithelioma and pleomorphic adenoma but Actin not expressed in the duct lining cells of pleomorphic adenoma. Conclusions The tumors comprised noplastic myoepithalial cells from salivary glands derive from the stem cells of intercalated cells.The tumor should be myoepithelioma if the predominant differentiation of the stem cells is toward myoepithalial cells;it should be nonomorphic adenoma if that is toward duct luminal epithelial cells;pleomorphic adenoma should be differentiation toward both myoepithalial cells and duct epithelial cells.