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| 亚低温对肝缺血再灌注后超微结构的保护作用 | |
| 引用本文： | 张涛,姜立华,扬新,吴义方,何劲松,吕新生. 亚低温对肝缺血再灌注后超微结构的保护作用[J]. 中国现代医学杂志, 2001, 11(7): 22-24 |
| 作者姓名： | 张涛 姜立华 扬新 吴义方 何劲松 吕新生 |
| 作者单位： | 1. 广东省粤北人民医院普外科 2. 中山医科大学电镜中心 3. 现为中山医科大学附二医院肝胆外科博士研究生 4. 中南大学湘雅医院普外科 |
| 基金项目： | 本文为广东省卫生厅立项资助课题(基金号 A1998584) |
| 摘 要： | 目的观察亚低温(33～35℃)对肝缺血再灌注损伤超微结构的影响。方法将18只犬随机分为三组，非缺血对照组、缺血再灌注组和亚低温组。用透射电镜观察各组肝组织超微结构改变。结果肝缺血再灌注组超微结构损伤较重；亚低温组超微结构改变较小，与缺血再灌注组比较线粒体保护较好(P＜0.01)。结论亚低温对肝缺血再灌注后的超微结构具有保护作用。 |
| 关 键 词： | 亚低温 缺血再灌注 肝损伤 超微结构 |
| 修稿时间： | 2000-11-10 |
Protective Effects of Mild Hypothermia on Ultrastructural Damage to Liver after Hepatic Ischemia-Reperfusion |
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| Zhang Tao,He Jinsong,Jian Lihua,et al. Protective Effects of Mild Hypothermia on Ultrastructural Damage to Liver after Hepatic Ischemia-Reperfusion[J]. China Journal of Modern Medicine, 2001, 11(7): 22-24 | |
| Authors: | Zhang Tao He Jinsong Jian Lihua et al |
| Affiliation: | Zhang Tao,He Jinsong,Jian Lihua,et al Department of General Surgery,People's Hospital of Yubei,Guangdong Province,Shaoguan 512026[ |
| Abstract: | Objective:To observe the effect of mild hypothermia on ultrastructual damage to liver induced by ischemia-reperfusion (I-R) injury.Methods:Eighteen dogs were randomly divided into three groups:nonischemic controls (C) group (n=6),ischemia-reperfusion (I-R) group(n=6) and mild hypothermia treatment (H) group (n=6).To observe the ultrastructural changes of liver by electron microscope.Results:Ultrastructural damage to liver was more severe in I-R;Ultrastructual changes of liver was mild and protective effects to mitochondria was better in H than in I-R(P<0.01).Conclusions:Mild Hypothermia has protective effects on ultrastructural damage to liver after ischemia-reperfusion. |
| Keywords: | Mild hypothermia Ischmia-Reperfusion Injury Liver |
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