Abstract: | Phasic changes in the immune response were observed in rats and mice with adjuvant disease: stimulation of antibody formation on the seventh day after injection of Freund's complete adjuvant (FCA) and inhibition on the 21st day. Inhibition of production of normal antibodies against 0- and Vi-typhoid antigens also was demonstrated.Laboratory for the Study of Nonspecific Resistance of the Organism and Immunity, Institute of General Pathology and Pathophysiology, Academy of Medical Sciences of the USSR, Moscow. (Presented by Academician of the Academy of Medical Sciences of the USSR A. M. Chernukh.) Translated from Byulleten' Éxperimental'noi Biologii i Meditsiny, Vol. 86, No. 10, pp. 462–465, October, 1978. |