Low frequency of HIV-1 tropism evolution in patients successfully treated for at least 2 years |
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| Authors: | Soulie Cathia Lambert-Niclot Sidonie Wirden Marc Simon Anne Valantin Marc-Antoine Fourati Slim Tubiana Roland Katlama Christine Calvez Vincent Marcelin Anne-Geneviève |
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| Affiliation: | Université Pierre et Marie Curie-Paris, UMR S, France. cathia.soulie@psl.aphp.fr |
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| Abstract: | The aim of this study was to analyse tropism evolution in HIV-1 patients with at least 2 years of viral load undetectability. For this purpose, HIV-1-infected antiretroviral-treated patients (n = 128) with a viral load less than 50 copies/ml for 4 years in median were studied. No change of virus tropism was observed in 92.9% of patients. Therefore, before the use of CCR5 antagonists, genotypic viral DNA tropism determination is an available tool. |
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