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| 雷公藤多甙对糖皮质激素受体的影响 | |
| 引用本文： | 刘毅,叶松柏,金彰红.雷公藤多甙对糖皮质激素受体的影响[J].川北医学院学报,2000,15(2):4-6. |
| 作者姓名： | 刘毅 叶松柏 金彰红 |
| 作者单位： | 1. 川北医学院药理教研室,四川南充 637000 2. 华西医科大学药理教研室,成都 610000 3. 浙江新昌第二制药厂,浙江新昌 312500 |
| 摘 要： | 目的 :研究雷公藤多甙对大鼠脾细胞GCR的影响。方法 :用雷公藤多甙处理ADI和ADX大鼠以及体外培养的大鼠脾细胞 ,检测大鼠脾细胞GCR、cAMP、对PHA的增殖反应和血浆CS。结果 :雷公藤多甙能升高脾细胞GCR数量、cAMP浓度、降低PHA的增殖反应和升高血浆CS浓度。结论 :雷公藤多甙降低大鼠脾细胞对PHA的增殖反应可能与升高GCR有关。 |
| 关 键 词： | 雷公藤多甙 皮质激素受体 环磷酸腺苷 皮质酮 |
| 文章编号： | 1005-3697(2000)02-0004-03 |
| 修稿时间： | 1999年11月9日 |
Effects of tripterygium wilfordii polyglycosidium (TWP) on glucocorticoid receptor in rat splenocytes |
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| LIU Yi ,YE Song-bai,JIN Zhang-hong.Effects of tripterygium wilfordii polyglycosidium (TWP) on glucocorticoid receptor in rat splenocytes[J].Journal of North Sichuan Medical College,2000,15(2):4-6. | |
| Authors: | LIU Yi YE Song-bai JIN Zhang-hong |
| Institution: | LIU Yi 1,YE Song-bai,JIN Zhang-hong |
| Abstract: | Aim To study the effects of TWP on glucocorticoid receptor in rat splenocytes.Methods Adrenal-intact and adrenalectomized rats and rat splenocytes in vitro were treated with TWH.The glucocorticoid receptor,the cAMP concentration,the profileration function to PHA in the rat splenocytes and serum corticosteroid concentration in the rats were examined.Results TWP was able to increase the glucocorticoid receptor content and the cAMP concentration,and to suppress the profileration function to PHA in rat splenocytes.TWP was also found to increase serum corticosteroid level in adrenal-inact rat.Conclusion The increase of glucocorticoid receptor content of TWH may be corrected with suppressing the profileration function of rat splenocytes to PHA. |
| Keywords: | tripterygium wilfordii polyglycosidium glucocorticoid receptor cAMP corticosteroid |
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