| 基于累积Meta分析的活血化瘀类中药复方预防全髋关节置换术后深静脉血栓疗效及安全性研究＊ |
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| 引用本文： | 黄和涛,潘建科,杨伟毅,曾令烽,梁桂洪,罗明辉,陈红云,刘军. 基于累积Meta分析的活血化瘀类中药复方预防全髋关节置换术后深静脉血栓疗效及安全性研究＊[J]. 世界科学技术-中医药现代化, 2020, 22(7): 2234-2246 |
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| 作者姓名： | 黄和涛 潘建科 杨伟毅 曾令烽 梁桂洪 罗明辉 陈红云 刘军 |
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| 作者单位： | 广州中医药大学第二临床医学院 广州 510405;广州中医药大学第二附属医院(广东省中医院) 广州510120 |
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| 基金项目： | 国家自然科学基金资助项目（No.81873314）:miR-675靶向TBK1介导骨关节炎免疫微环境调控软骨细胞自噬及补肾活血中药干预研究,负责人：刘军;广东省财政厅项目经费（No.［2014］157号）：中老年退行性膝骨关节炎中医药防治管理体系,负责人：刘军。 |
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| 摘 要： | 目的 基于累积Meta分析,系统评价活血化瘀类中药复方预防全髋关节置换术后深静脉血栓的疗效及安全性。方法 全面检索PubMed、The Cochrane Library、EMbase、中国知网（CNKI）、中国生物医学文献数据库（CBM）、维普数据库（VIP）、万方数据库等国内外权威数据库,运用STATA 14.0进行累积Meta分析。结果 共纳入30篇文献,按照发表年限进行累积Meta分析提示活血化瘀类中药复方预防THA术后DVT有确切疗效初次被证明是在2015年,OR=0.59,95%CI[0.41,0.85],其OR值停留在0.38,95% CI[0.30,0.48],提示治疗组DVT发生率低于对照组;运用Egger检验法进行发表偏移检验,P=0.005＜0.05,其95% CI[-2.37,-0.46]不包含0,提示发表偏倚可能性大,考虑与纳入文献质量较低相关,后期研究应增加高质量文献以减少发表偏倚。按发表年限进行累积Meta分析提示活血化瘀类中药复方减少THA术后不良反应发生率初次被证明有效是在2016年,OR=0.15,95%CI[0.04,0.62],其OR值停留在0.32,95% CI[0.19,0.56],提示治疗组在减少不良反应发生率方面优于对照组;按样本量进行累积Meta分析提示其OR值停留在0.32,95% CI[0.19,0.56],亦提示治疗组在减少不良反应发生率方面优于对照组;运用Egger检验法进行发表偏移检验,P=0.476＞0.05,其95% CI[-12.62,7.49]包含0,提示发表偏倚可能性小。结论 活血化瘀类中药预防THA术后DVT是一种安全有效的治疗方法,但更加确切的结论仍需高质量大样本多中心的随机对照试验加以验证。
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| 关 键 词： | 累积Meta分析 活血化瘀类中药 全髋关节置换术 深静脉血栓 疗效评价安全性 |
| 收稿时间： | 2019-07-23 |
| 修稿时间： | 2020-07-02 |
Efficacy and Safety of Chinese Herbal Compounds for Promoting Blood Circulation and Removing Blood Stasis to Prevent Deep Venous Thrombosis after Total Hip Arthroplasty Based on Cumulative Meta-Analysis |
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| Huang Hetao,Pan Jianke,Yang Weiyi,Zeng Lingfeng,Liang Guihong,Luo Minghui,Chen Hongyun and Liu Jun. Efficacy and Safety of Chinese Herbal Compounds for Promoting Blood Circulation and Removing Blood Stasis to Prevent Deep Venous Thrombosis after Total Hip Arthroplasty Based on Cumulative Meta-Analysis[J]. World Science and Technology—Modernization of Traditional Chinese Medicine and Materia Medica, 2020, 22(7): 2234-2246 |
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| Authors: | Huang Hetao Pan Jianke Yang Weiyi Zeng Lingfeng Liang Guihong Luo Minghui Chen Hongyun Liu Jun |
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| Affiliation: | Second School of Clinical Medicine, Guangzhou University of Chinese Medicine, Guangzhou 510405, China,Department of Orthopaedics, Second Affiliated Hospital of Guangzhou University of Chinese Medicine, Guangdong Provincial Hospital of Chinese Medicine, Guangzhou 510120, China,Department of Orthopaedics, Second Affiliated Hospital of Guangzhou University of Chinese Medicine, Guangdong Provincial Hospital of Chinese Medicine, Guangzhou 510120, China,Department of Orthopaedics, Second Affiliated Hospital of Guangzhou University of Chinese Medicine, Guangdong Provincial Hospital of Chinese Medicine, Guangzhou 510120, China,Department of Orthopaedics, Second Affiliated Hospital of Guangzhou University of Chinese Medicine, Guangdong Provincial Hospital of Chinese Medicine, Guangzhou 510120, China,Department of Orthopaedics, Second Affiliated Hospital of Guangzhou University of Chinese Medicine, Guangdong Provincial Hospital of Chinese Medicine, Guangzhou 510120, China,Department of Orthopaedics, Second Affiliated Hospital of Guangzhou University of Chinese Medicine, Guangdong Provincial Hospital of Chinese Medicine, Guangzhou 510120, China,Department of Orthopaedics, Second Affiliated Hospital of Guangzhou University of Chinese Medicine, Guangdong Provincial Hospital of Chinese Medicine, Guangzhou 510120, China |
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| Abstract: | |
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| Keywords: | Cumulative meta-analysis Chinese medicine for promoting blood circulation and removing blood stasis Total hip arthroplasty Deep venous thrombosis Efficacy evaluation Safety |
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