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AMPK-associated signaling to bridge the gap between fuel metabolism and hepatocyte viability |
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| Authors: | Yoon Mee Yang Chang Yeob Han Sang Geon Kim Innovative Drug Research Center for Metabolic Inflammatory Disease College of Pharmacy Seoul National University Seoul - South Korea Yoon Jun Kim |
| Institution: | Yoon Mee Yang,Chang Yeob Han,Sang Geon Kim,Innovative Drug Research Center for Metabolic and Inflammatory Disease,College of Pharmacy,Seoul National University,Seoul 151-742,South Korea Yoon Jun Kim,Department of Internal Medicine and Liver Research Institute,Seoul National University College of Medicine,Seoul 110-744,South Korea |
| Abstract: | The adenosine monophosphate-activated protein kinase (AMPK) and p70 ribosomal S6 kinase-1 pathway may serve as a key signaling flow that regulates energy metabolism; thus, this pathway becomes an attractive target for the treatment of liver diseases that result from metabolic derangements. In addition, AMPK emerges as a kinase that controls the redox-state and mitochondrial function, whose activity may be modulated by antioxidants. A close link exists between fuel metabolism and mitochondrial biogenesis. Th... |
| Keywords: | Adenosine monophosphate-activated protein kinase Cell survival Energy metabolism Fatty liver Insulin resistance Glycogen synthase kinase 3β p70 ribosomal S6 kinase-1 |
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