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| 三黄喷雾剂体外透皮吸收 | |
| 引用本文： | 朱鹏飞,冯伟红,杜茂波,王洪珍,李颖,刘树扬,吴志成,刘淑芝. 三黄喷雾剂体外透皮吸收[J]. 中国实验方剂学杂志, 2012, 18(12): 15-17 |
| 作者姓名： | 朱鹏飞 冯伟红 杜茂波 王洪珍 李颖 刘树扬 吴志成 刘淑芝 |
| 作者单位： | 1. 首都医科大学,北京,100069 2. 中国中医科学院中药研究所,北京,100700 3. 通化万通药业股份有限公司,吉林通化,134001 |
| 基金项目： | 重大新药创制项目(2009ZX09502-010, 2009ZX09301-005-05);中国中医科学院自主选题项目(Z02094) |
| 摘 要： | 目的:考察三黄喷雾剂小鼠体外经皮渗透规律.方法:采用垂直式改良Franz扩散池装置进行试验,以黄芩苷和盐酸小檗碱含量为考察指标,HPLC测定接受液中指标成分含量.结果:黄芩苷、盐酸小檗碱的透皮速率分别为42.35,49.99 μg·cm-2·h-1;黄芩苷、盐酸小檗碱6h平均累积透过率分别为19.51％,7.17％.结论:三黄喷雾剂小鼠体外透皮吸收效果理想,透皮行为符合零级方程. |
| 关 键 词： | 三黄喷雾剂 透皮吸收 黄芩苷 盐酸小檗碱 |
| 收稿时间： | 2011-12-19 |
Transdermal Absorption of Sanhuang Spray in vitro |
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| ZHU Peng-fei,FENG Wei-hong,DU Mao-bo,WANG Hong-zhen,LI Ying,LIU Shu-yang,WU Zhi-cheng and LIU Shu-zhi. Transdermal Absorption of Sanhuang Spray in vitro[J]. China Journal of Experimental Traditional Medical Formulae, 2012, 18(12): 15-17 | |
| Authors: | ZHU Peng-fei FENG Wei-hong DU Mao-bo WANG Hong-zhen LI Ying LIU Shu-yang WU Zhi-cheng LIU Shu-zhi |
| Affiliation: | Capital Medical University,Beijing 100069,China;Institute of Chinese Materia Medica, China Academy of Chinese Medical Sciences, Beijing 100700, China;Institute of Chinese Materia Medica, China Academy of Chinese Medical Sciences, Beijing 100700, China;Wantong Phermaautical Co.Led,Tonghua 134001,China;Wantong Phermaautical Co.Led,Tonghua 134001,China;Capital Medical University,Beijing 100069,China;Institute of Chinese Materia Medica, China Academy of Chinese Medical Sciences, Beijing 100700, China;Institute of Chinese Materia Medica, China Academy of Chinese Medical Sciences, Beijing 100700, China |
| Abstract: | Objective:To investigate in vitro percutaneous penetration law of Sanhuang spray in mice.Method:Vertical modified Franz diffusion cell device was used with the content of baicalin and berberine hydrochloride as indexes,index ingredients in receiving liquid were determined by HPLC.Result: Transdermal rates of baicalin and berberine hydrochloride were 42.35,49.99 μg · cm-2·h-1,respectively;Average cumulative penetration rate of baicalin and berberine hydrochloride in 6 h were 19.51%,7.17%,respectively.Conclusion: In vitro transdermal absorption effect in mice of Sanhuang spray was ideal,transdermal behavior was in accordance with zero-level equation. |
| Keywords: | Sanhuang spray transdermal absorption baicalin berberine hydrochloride |
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