| 肠促胰素在血糖稳态调节和2型糖尿病治疗中的作用 |
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| 引用本文： | 宁光. 肠促胰素在血糖稳态调节和2型糖尿病治疗中的作用[J]. 中华内分泌代谢杂志, 2010, 26(9). DOI: 10.3760/cma.j.issn.1000-6699.2010.09.032 |
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| 作者姓名： | 宁光 |
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| 作者单位： | 上海市内分泌代谢病研究所,上海市内分泌代谢病临床医学中心,上海交通大学附属瑞金医院内分泌代谢病科,200025 |
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| 摘 要： | 肠促胰素(incretin)是一类在食物营养物质刺激下,由肠道内分泌细胞合成分泌的激素,具有葡萄糖依赖性促胰岛素分泌的特性,可通过促进β细胞的胰岛素分泌、抑制α细胞不适当的胰升糖素分泌、延缓胃排空及抑制食欲等多个途径参与机体血糖稳态调节.同时,肠促胰素还可促进β细胞增殖、抑制β细胞凋亡,增加胰岛素合成、改善β细胞功能,从而延缓甚至逆转2型糖尿病病程的进展.以肠促胰素为基础的治疗方案,包括胰升糖素样肽-1(GLP-1)类似物和二肽基肽酶-4(DPP-4)抑制剂将为2型糖尿病的治疗开辟一条新的途径.
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| 关 键 词： | 肠促胰素 血糖稳态 糖尿病,2型 |
The role of incretin in the regulation of glucose homeostasis and treatment of type 2 diabetes |
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| NING Guang. The role of incretin in the regulation of glucose homeostasis and treatment of type 2 diabetes[J]. Chinese Journal of Endocrinology and Metabolism, 2010, 26(9). DOI: 10.3760/cma.j.issn.1000-6699.2010.09.032 |
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| Authors: | NING Guang |
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| Abstract: | Incretins are glucose-dependent insulinotropic hormones that are secreted from intestinal endocrine cells stimulated by meal nutrients after eating. Incretins can maintain glucose homeostasis through promoting insulin secretion from β cell and suppressing inappropriately glucagon secretion from α cell, as well as many other physiological effects. Furthermore, incretins can delay and even reverse the deterioration of type 2 diabetes by enhancing islet β cell function. Incretin-based therapies, including glucagon-like peptide-1 mimetics and dipeptidyl peptidase-Ⅳ inhibitors, will bring us new insights into the treatment of type 2 diabetes. |
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| Keywords: | Incretin Glucose homeostasis Diabetes mellitus,type 2 |
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