早发冠心病患者合并非乙醇性脂肪性肝病的发生率及危险因素

目的 :探讨早发冠心病患者非乙醇性脂肪性肝病(non-alcoholic fatty liver disease,NAFLD)的患病率和危险因素。方法:冠状动脉造影诊断为早发冠心病的748例患者,入院期间进行空腹肝胆超声检查。结果:NAFLD患者发生率为49.6%(371/748)。NAFLD组糖尿病,血清总胆固醇,三酰甘油,血清丙氨酸转氨酶及天冬氨酸转氨酶高于非NAFLD组,差异有统计学意义(P<0.05)。NAFLD组多支病变比率明显高于非NAFLF组(χ2=4.455,P=0.04)。多因素Logistic回归分析中,只有糖尿病和冠心病左主干病变是NAFLD的危险因素。结论:早发冠心病患者中NAFLD发生率高达50%,其中冠状动脉多支病变和糖尿病与NAFLD的发生密切相关。

Prevalence of non-alcoholic fatty liver disease in premature coronary heart disease and risk factor

Objective: The aim of this study was to investigate the incidence and risk factor of non-alcoholic fatty liver disease NAFLD in premature coronary artery disease in patients undergoing coronary angiogram.Methods: 748 patients with premature coronary artery disease who underwent coronary angiogram were enrolled into this study.All patients had ultrasound screening for fatty liver.Results: Among 748 recruited patients,341(49.6%)had fatty liver by ultrasonography.Incidence of NAFLD in the patients in multi-vessel disease was higher than those of 1-vessel disease(χ2=4.455,P=0.04).By multivariable logistic regression analysis,diabetes mellitus,stenosis of left main stem were risk factor in NAFLD patients with premature coronary heart disease.Conclusion: Incidence of NAFLD was about 50% in premature coronary artery disease patients.The presence of NAFLD is associated with multi-vessel disease and diabetes mellitus.