Sex and strain differences in benzodiazepine receptor binding in Roman rat strains |
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| Authors: | R A Shephard E B Nielsen P L Broadhurst |
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| Affiliation: | 1. Department of Psychology, University of Birmingham, P.O. Box 363, Birmingham, B15 2TT, England;2. Psychopharmacological Research Laboratory, Department E, Sct. Hans Hospital, 4000 Roskilde, Denmark |
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| Abstract: | Specific [3H]flunitrazepam binding was determined for five brain regions in both sexes of the three Roman rat strains. Small strain differences and a large Sex-Region interaction were detected, benzodiazepine receptor binding being significantly higher in females in the two cortical areas and the cerebellum, but significantly lower in the striatum and hippocampus. These findings are discussed in the context of sex and strain differences in behavior and benzodiazepine sensitivity. |
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| Keywords: | Benzodiazepine receptors Rats Roman strain Sex differences Brain region |
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