Effect of ageing on circadian rhythms of plasma renin and aldosterone in mesor-hypertensive women |
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Authors: | P. Cugini F. Halberg R.B. Sothern G. Cornelissen M. Lisanu R. Romassini P. Lucia E. Salandi D. Scavo |
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Affiliation: | 1. I Patologia Medica, University of Rome, Rome, Italy;2. Chronobiology Laboratories, University of Minnesota, Minneapolis, MN, U.S.A. |
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Abstract: | This study investigated the changes in circadian rhythms of plasma renin activity (PRA) and plasma aldosterone (PA) which occur in essential mesor-hypertensive women, increasing in age. Systemic blood samples were taken throughout a 12 h period from both mesor-hypertensive women and clinically healthy women (control). The women in each group were either post-menopausal or had normal menstrual cycles. A cosinor method of temporal series was the analysis employed to compute the properties of PRA and PA circadian rhythms.The clearest effect of ageing, recorded in essential mesor-hypertensive women, is a decrease in circadian mesor of PRA cycle (P = 0.002). The age-related changes in clinically healthy women appear to be more extensive and involve a decrease for both mesor (P < 0.001) and amplitude (P = 0.007) of PRA circadian rhythm. These disparities are convincing evidence for a non-physiological decline of the RAAS rhythmic function in the aged essential mesor-hypertensive women. The lack of an age-associated decrease in circadian PRA amplitude merits a pathophysiological and clinical investigation because it is a possible risk factor for post-menopausal, essential mesor-hypertensive women. |
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Keywords: | Ageing Aldosterone Angiotensin Circadian rhythm Mesor-hypertension Renin |
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