The effect of lamivudine on the replication of hepatitis B virus in HIV-infected patients depends on the host immune status (CD4 cell count) |
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Authors: | Haverkamp Margje Smit Maarten Weersink Annemarie Boucher Charles A Hoepelman Andy I |
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Affiliation: | Department of Medicine, Division of Acute Medicine and Infectious Diseases, Utrecht, The Netherlands. |
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Abstract: | We retrospectively analysed the effect of lamivudine on hepatitis B virus (HBV) in HIV-co-infected patients. In this small study we document a CD4 cell-dependent response on HBV replication with lamivudine therapy. In this respect, hepatitis B may be considered an opportunistic infection. Our finding may have important clinical consequences, and large prospective studies are necessary to investigate this further. |
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