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| 应激时大鼠垂体前叶血管紧张素原基因表达增强 | |
| 引用本文： | 张素珍,徐永,万瑜,杨钢,唐志佼,胡建民.应激时大鼠垂体前叶血管紧张素原基因表达增强[J].中国病理生理杂志,2002,18(5):540-542. |
| 作者姓名： | 张素珍 徐永 万瑜 杨钢 唐志佼 胡建民 |
| 作者单位： | 1. 广东医学教研室, 广东湛江 524023; 2. 广东医学理生理教研室, 广东湛江 524023; 3. 武汉大学医学理教研室, 湖北武汉 430071; 4. 武汉大学医学理教研室, 湖北武汉 430071; 5. 武汉大学医学验中心, 湖北武汉 430071 |
| 摘 要： | 目的:观察应激时大鼠垂体前叶血管紧张素原mRNA表达及血管紧张素Ⅱ含量的变化。方法:用原位杂交技术及放免分析法检测应激大鼠垂体前叶血管紧张素原(ANG)mRNA的表达及血管紧张素Ⅱ(AngⅡ)含量。结果:应激时垂体前叶ANGmRNA表达及AngⅡ含量均显著增高,且ANGmRNA表达增高率超过了AngⅡ含量的增高率。结论:应激时垂体前叶肾素-血管紧张素系统(RAS)被显著激活,进一步支持局部RAS参与了应激反应的观点。 |
| 关 键 词： | 应激 垂体 前叶 血管紧张素原 杂交 |
| 文章编号： | 1000-4718(2002)05-0540-03 |
| 收稿时间： | 2001-07-10 |
Stress induced expression of the angiotensinogen gene in rat anterior pituitary |
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| XU Yong ,ZHANG Su-zhen ,WAN Yu ,YANG Gang ,TANG Zhi-jiao ,HU Jian-min.Stress induced expression of the angiotensinogen gene in rat anterior pituitary[J].Chinese Journal of Pathophysiology,2002,18(5):540-542. | |
| Authors: | XU Yong ZHANG Su-zhen WAN Yu YANG Gang TANG Zhi-jiao HU Jian-min |
| Institution: | 1. Department of Physiology, Guangdong Medical College, Zhanjiang 524023, China; 2. Department of Pathophysiology, Guangdong Medical College, Zhanjiang 524023, China; 3. Department of Physiology, Medical College of Wuhan University, Wuhan 430071, China; 4. Department of Pathology, Medical College of Wuhan University, Wuhan 430071, China; 5. Experimental Centre, Medical College of Wuhan University, Wuhan 430071, China |
| Abstract: | AIM:To investigate the expression of angiotensinogen (ANG)mRNA and the changes of AngⅡ content in rat anterior pituitary during acute stress.METHODS:The expression of ANG mRNA was determined usingin situhybridization technique, and the AngⅡ content were determined by RIA.RESULTS:The ANG mRNA expression and AngⅡ content were significantly increased, and ANG mRNA was increased more significantly than AngⅡ content. CONCLUSION:The local renin-angiotensin system (RAS) in anterior pituitary is obviously activated during stress, which strongly supports the view that local RAS contributes to stress reaction. |
| Keywords: | Stress Pituitary gland anterior Angiotensinogen Hybridization |
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