丙泊酚复合瑞芬太尼用于人工流产的临床观察

目的:探讨丙泊酚复合瑞芬太尼用于人工流产的可能性,为在门诊开展此类手术的安全性提供依据。方法:选择ASAI-Ⅱ级,妊娠6-10周自愿请求终止妊娠者80例,随机分成二组,瑞芬太尼组(R组)和丙泊酚组(P组)。R组:瑞芬太尼1.0ug/kg先缓慢静注30s,随后以0.15ug/kg/min持续微量泵入,瑞芬太尼诱导结束后缓慢静注丙泊酚1.0mg/kg.P组单纯缓慢静注丙泊酚2.0-2.5mg/kg,术中根据患者体动反应间断追加丙泊酚0.5-1.0mg/kg.结果:二组患者中,R组麻醉效果明显优于P组,二组患者给药2min后血流动力学变化与术前比较均有显著性差异,尤以P组明显,但手术结束时的血流动力学变化与术前比较无明显差异。二组不良反应P组多于R组。结论:丙泊酚复合瑞芬太尼用于人工流产,不仅麻醉效果确实,而且明显减少丙泊酚用量,减轻病人经济负担,可安全地在门诊进行。

Clinical observation of propofol combined with remifentanil infusion in the artificial abortion

Objective:To investigate the effect of propofol combined with remifentanil infusion in the artificial abortion.Methods:Eighty early pregnant patients under the general anesthesia were randomly divided into two groups.The patients in study group received intravenous remifentanil and propofol,and these in control group received propofol alone.In study group,a bolus dose of remifentanil 1.0ug/kg was given,and in a dose of 0.15ug/kg/min was pumped during operation.Propofol of 2.0-2.5mg/kg was injected,and at 0.5-1.0mg/kg was injected according to the patients response.Results:The anesthesia efficacy of study group was superior to that of control group.A better recovery and less side effects were found in study group than those in control group.Conclusions:The propofol combined with remifentanil infusion in the artificial abortion is not only effective and safety,but also can be preformed in the out-patient econonically.