针刺对急性局灶性脑缺血大鼠脑组织神经节苷脂含量的影响

目的：研究针刺对急性局灶性脑缺血大鼠脑组织神经节苷脂含量的影响。方法：选取204只Wistar雄性大鼠，随机分为正常组(10只)、模型组(64只)、针刺组(64只)和药物组(66只)。后3组通过线栓法造成大鼠左侧大脑中动脉栓塞，并于栓塞后5min给予针刺组针刺治疗，给予药物组腹腔注射施捷因注射液(10mg／kg体重)。分别于栓塞后1h、2h、3h、5h、7h、12h和24h测定各组大鼠脑组织中神经节苷脂结合唾液酸含量。结果：急性脑缺血后，大鼠脑组织中神经节苷脂结合唾液酸含量随时间呈明显下降趋势，但针刺组与药物组的神经节苷脂结合唾液酸含量明显高于模型组，且两组的疗效相当，仅2h、3h和5h的疗效有差异。结论：针刺能调节脑组织中神经节苷脂含量以起到脑保护、促进神经重构的作用。

Effects of acupuncture on ganglioside in rats with acute cerebral ischemia

ObjectiveTo approach effects of acupuncture on ganglioside in rats with acute cerebral ischemia.Methods204 Wistar rats were randomly divided into the normal group, model group, acupuncture group and medicine group, and middle cerebral artery embolism has been made by thread-ligation method in the latter three groups. Ganglioside content in the rat brain had been measured respectively after cerebral ischemia 1, 2, 3, 5, 7, 12 and 24 hours.ResultsThe content of lipid-bound sialic acid (LBSA) has decreased significantly after the acute cerebral ischemia, but LBSA contents of the acupuncture group and medicine group were higher significantly than that of the model group, and these two groups have been similar in curative effect, and have difference only at embolism 2, 3 and 5 hours.Conclusion Acupuncture can regulate ganglioside and play the role of cerebral protection and neuroplasticity.