多巴胺、地高辛、ACEI、呋塞米联合用治疗难治性心衰21例疗效观察

目的总结多巴胺、地高辛、ACE I、呋塞米合用治疗难治性心力衰竭的价值。方法对21例难治性心衰(心功能Ⅲ级9例,Ⅳ级12例)采用多巴胺静滴,地高辛、卡托普利或依那普利口服,呋塞米静注5~7 d,观察心功能、心脏每搏排出量(SV)、射血分数(EF)、心脏指数(C I)、心肌耗氧量变化情况。结果显效12例(57.1%),有效7例(33.3%),无效2例(9.6%);EF,SV,C I治疗后均较治疗前显著提高(P<0.01);心肌耗氧量治疗后较治疗前明显降低(P<0.01)。结论多巴胺、地高辛、ACE I、呋塞米合用治疗难治性心力衰竭,疗效佳、安全。

Dopamine, Digoxin, ACEI and Furosemide were Jointly Applied to Refractory Heart Failure

Objective To summarize the value of dopamine,digoxin,angiotesin converting enzyme inhibitor(ACEI) and furosemide in the treatment of refractory heart failure.Methods Twenty-one patients with refractory heart failure were treated with dopamine(intravenous drip),oral digoxin,captopril or enalapril and intravenous furosemide for 5-7 days.Then,the changes in heart function,stroke volume(SV),ejection fraction(EF),cardiac index(CI) and myocardial oxygen consumption were observed.Results Of the 21 patients,12(57.1%) achieved obvious effect, seven(33.3%) achieved ordinary effect and two(9.6%) achieved no effect.The parameters after treatment such as EF,SV and CI rose significantly,and myocardial oxygen consumption went down significantly(P<0.01).Conclusion Joint dopamine,digoxin,ACEI and furosemide are effective on refractory heart failure.