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Gonadotropin-releasing hormone receptors as molecular therapeutic targets in prostate cancer: Current options and emerging strategies |
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| Authors: | Patrizia Limonta Marilena Manea |
| Institution: | 1. Dipartimento di Scienze Farmacologiche e Biomolecolari, Università degli Studi di Milano, Milano, Italy;2. Laboratory of Analytical Chemistry and Biopolymer Structure Analysis, Department of Chemistry, University of Konstanz, Konstanz, Germany;3. Zukunftskolleg, University of Konstanz, Konstanz, Germany |
| Abstract: | Prostate cancer is androgen-dependent in its early stages and androgen deprivation therapy represents the most effective first-line therapeutic approach. However, after an initial remission, prostate cancer progresses towards the castration resistant prostate cancer (CRPC) stage, with increased malignancy and resistance to conventional chemotherapy. |
| Keywords: | Gonadotropin-releasing hormone (GnRH) GnRH receptors Prostate cancer Castration resistant Targeted therapy GnRH agonists GnRH antagonists GnRH-II GnRH-III GnRH-based cytotoxic hybrids |
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