急性脑梗死患者同型半胱氨酸和血脂水平变化及其相关性分析

目的 探讨急性脑梗死患者同型半胱氨酸（Hcy）和血脂水平的变化及其相关性.方法 选择2012年入住我院治疗的急性脑梗死患者116例作为研究组,选择同期我院体检健康者102例作为对照组,研究组患者于入院次日晨起（24 h内） 空腹、对照组于体检当日晨起空腹抽取肘静脉血,测定Hcy和血脂水平.结果 研究组血清Hcy、TG、TC、LDL-C、极低密度脂蛋白（VLDL）、脂蛋白a[Lp（a）]水平均高于对照组（P＜0.05）,而HDL-C、载脂蛋白A（ApoA）水平低于对照组（P＜0.05）;Hcy与HDL-C、ApoA呈负相关（r值分别为 -0.184、-0.316,P＜0.05）.结论 高Hcy、血脂异常与急性脑梗死的发生相关,Hcy升高可能与HDL-C、ApoA降低相关,联合检测上述指标对急性脑梗死的预防及治疗均有重要意义.

Changes of Homocysteine and Blood Lipid in the Patients with Acute Cerebral Infarction and Their Correlation

Objective To investigate the changes of homocysteine （Hcy） and blood lipid in patients with acute cerebral infarction and their correlation. Methods .116 patients with acute cerebral infarction were selected as study group in our hospital in 2012, at the same time, 102 healthy cases undergoing physical examination in our hospital were selected as control group. The cubital vein blood were distilled in the two groups, thereinto patients of study group distilled fasting vein blood at the next morning （24 h inside） after admission, the cases of control group distilled fasting vein blood at the examination day morn- ing. Levels of Hcy and blood lipid were detected. Results The levels of serum Hcy, TG, TC, LDL - C, very low density lip- oprotein （VLDL）, lipoprotein a [Lp （a） ~ of study group were higher than those of control group （P 〈0. 05） ; The levels of HDL- C, apolipoprotein A （ApoA） were lower than those of control group （P 〈0. 05） ; The level of Hcy had negative correla- tion with HDL -C and ApoA （r = -0. 184, -0. 316, P 〈 0. 05）. Conclusion High Hcy and dyslipidemia are closely related to acute cerebral infarction, increasing of Hcy may be related to reducing of HDL - C and ApoA, detecting the above indicators have great significances for the prevention and treatment of acute cerebral infarction.