乙肝病毒载量对妊娠期糖尿病患者妊娠结局的影响

目的探讨分析乙肝病毒（HBV）携带载量对妊娠期糖尿病（GDM）患者妊娠结局的影响。方法选取2011年1月至2013年6月门诊孕检及住院分娩的孕妇18985例，其中乙肝病毒携带者合并GDM患者386例，携带者中病毒载量阳性合并GDM患者168例设为A1组，病毒载量阴性者合并GDN患者218例为A2组，非乙肝病毒携带者合并GDM患者398例为B组，分别比较B组及A1、A2组的妊娠结局及对胎儿的影响情况。结果各组在早产、剖宫产、产后出血、胎龄和新生儿窒息等方面比较差异无显著性（P〉0．05）；B组产后出血量为250．27±10．42ml，低于A1组320．58±10．31ml和A2组310．42±9．46ml，差异有统计学意义（P〈0．05）；A1组和A2组新生儿体质量和产后出血量比较差异无显著性（P〉0．05）。结论非乙肝病毒携带者合并GDM患者产后出血量较少，乙肝病毒（HBV）携带载量水平不同对妊娠期糖尿病的妊娠结局没有影响。

Influence of hepatitis B virus load on the outcome of pregnancy with gestational diabetes mellitus.

Objective To investigate and analyze hepatitis B virus （HBV） carrying load of gestational diabetes mellitus （GDM） for influ- encing pregnancy outcome. Methods There was 18 985 pregnant and delivery women from January in 2011 to June in 2013 in our hospital, in- cluding 386 patients with hepatitis B virus carriers with GDM. 168 patients with viral load carriers positive with GDM were considered as group A1. Viral load in patients with GDM and 218 cases negative were considered A2 group, 398 non hepatitis B virus carriers with GDM as B group. The pregnancy outcome, 322 group and A1 of pregnant women with GDM and its influence on the fetus condition were compared with B group. Resuits There were no significant difference （ P 〉 0.05 ） in preterm labor, cesarean section, postpartum hemorrhage, fetal and neonatal asphyxia in three groups. Postpartum hemorrhage volume of B group was 250.27 ±10.42ml, which is lower than that in A1 group （320.58 ±10.31 ml） and A2 group（310.42 ±9.4 6 ml）. The difference was statistically significant difference （ P 〈0.05）. Between A1 group and A2 group, neo- natal birth weight and postpartum hemorrhage volume had no significant difference （ P 〉 0. 05 ）. Conclusion For patients with non carriers of hepatitis B virus with GDM, Postpartum hemorrhage volume were less, hepatitis B virus （HBV） carrying the load level did not affect the other pregnancy outcome.