| 蛋白质组学方法在玻璃体研究中的应用 |
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| 引用本文： | 林铁柱,褚光辉,王建伟,李世洋.蛋白质组学方法在玻璃体研究中的应用[J].国际眼科杂志,2014,14(3):474-476. |
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| 作者姓名： | 林铁柱 褚光辉 王建伟 李世洋 |
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| 作者单位： | 中国河南省洛阳市,解放军第150中心医院眼科;中国河南省洛阳市,解放军第150中心医院眼科;中国河南省洛阳市,解放军第150中心医院眼科;中国河南省洛阳市,解放军第150中心医院眼科 |
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| 摘 要： | 玻璃体以透明的凝胶状态充填于玻璃体腔内，当视网膜发生病变时，相邻的玻璃体的蛋白质构成会发生一些变化，这在很多研究中得到证实。最近10a，蛋白质组学技术被用来研究玻璃体的蛋白质组，希望发现与糖尿病性视网膜病变(diabetic retinopathy，DR)病因相关的特异蛋白质。最近对动物自身免疫性葡萄膜炎的玻璃体样本进行蛋白质组学研究，发现了与眼内炎症相关的特异蛋白质。
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| 关 键 词： | 玻璃体 蛋白质组学 糖尿病性视网膜病变 眼内炎症 葡萄膜炎 |
| 收稿时间： | 2013/10/23 0:00:00 |
| 修稿时间： | 2014/1/29 0:00:00 |
Proteomic analyses in the study of vitreous humour |
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| Tie-Zhu Lin,Guang-Hui Chu,Jian-Wei Wang and Shi-Yang Li.Proteomic analyses in the study of vitreous humour[J].International Journal of Ophthalmology,2014,14(3):474-476. |
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| Authors: | Tie-Zhu Lin Guang-Hui Chu Jian-Wei Wang and Shi-Yang Li |
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| Institution: | Department of Ophthalmology, the 150th Hospital of Chinese PLA,Luoyang 471031, Henan Province, China;Department of Ophthalmology, the 150th Hospital of Chinese PLA,Luoyang 471031, Henan Province, China;Department of Ophthalmology, the 150th Hospital of Chinese PLA,Luoyang 471031, Henan Province, China;Department of Ophthalmology, the 150th Hospital of Chinese PLA,Luoyang 471031, Henan Province, China |
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| Abstract: | Vitreoushumour(VH)is a transparent, highly hydrated gel, which occupies the vitreous cavity. The protein composition of the VH would change in pathological conditions of the retina, which has been testified in many studies. In the last decade, proteomics analyses have been performed to study the proteome of the human VH and hope to find some specific proteins in the aetiology of diabeticretinopathy(DR). Recent proteomic studies on the VH from animal models of autoimmune uveitis have identified some specific proteins in related entophthalmia. |
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| Keywords: | vitreous humour proteome diabetic retinopathy entophthalmia uveitis |
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