| 抗心律失常药盐酸索他洛尔的合成 |
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| 引用本文： | 程仁刚,聂进红,袁玉军.抗心律失常药盐酸索他洛尔的合成[J].齐鲁药事,2004,23(9):48-49. |
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| 作者姓名： | 程仁刚 聂进红 袁玉军 |
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| 作者单位： | 鲁南制药股份有限公司,临沂,276005 |
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| 摘 要： | 合成盐酸索他洛尔。方法 以苯胺为原料,经甲烷磺酰氯的酰化反应,溴乙酰溴的傅 -克酰化反应和异丙胺的分子间亲核取代反应及还原四步合成盐酸索他洛尔。结果及结论 经工艺改进,各步收率均有较大的提高,总收率达到 4 6 4 0 %。
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| 关 键 词： | 抗心律失常药 盐酸索他洛尔 |
| 文章编号： | 1672-7738(2004)09-0048-02 |
Synthesis of anti-arrhythmia drug Sotalol hydrochloride |
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| Cheng Reng-gang,Nie Jin-hong,Yuan Yu-jun.Synthesis of anti-arrhythmia drug Sotalol hydrochloride[J].qilu pharmaceutical affairs,2004,23(9):48-49. |
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| Authors: | Cheng Reng-gang Nie Jin-hong Yuan Yu-jun |
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| Abstract: | Objective To synthesis Sotalol hydrochloride.Methods In order to get Sotalol,benzenamine was acetylated by methylsulfonylchloride and bromoacetylbro mide b y turns,then substituted with isopropylamine by S N1 reaction and reduced in th e end.Results and Conclusion Yields of every steps can be rai sed by the imp roved synthesis method,and the total yield can reach 46.40%. |
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| Keywords: | anti-arrhythmia drug Sotalol hydrochloride |
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