牙周干预对环孢菌素A相关牙龈增生的预防效果观察

目的评价肾移植术前牙周基础治疗对环孢菌素A相关的牙龈增生的预防效果。方法选取即将行肾移植术且拟用环孢菌素A作为免疫抑制剂的患者20名,随机分为牙周干预组（A组）和对照组（B组）,在平衡了年龄、性别等干扰因素的前提下,记录被研究者移植术前及术后3个月、6个月、12个月时的牙周指标。结果两组的牙周指标在肾移植术前比较差异无统计学意义（P〉0.05）;在观察期间,我们发现A组的PLI、SBI、PD指数在3、6、12个月与0个月比较有所下降,且差异有统计学意义（P〈0.05）,GHI指数随着时间推移均数有所升高,但各时间点之间差异并无统计学意义（P〉0.05）;B组的PLI、SBI、PD、GHI逐渐升高,且差异均有统计学意义（P〈0.05）。结论牙周感染可能是肾移植术后环孢菌素A相关的牙龈增生的原因之一,术前进行牙周基础治疗对环孢菌素A相关的牙龈增生的发生有一定的预防作用。

The Prevention effect of basic periodontal therapy on gingival hyperplasia induced by cyclosporineA before renal transplantation

Objective To evaluate the prevention effect of basic periodontal therapy on gingival hyperplasia induced by cyclosporineA before renal transplanting surgery. Methods 20 renal transplanting patients were chosen and were randomly divided into two groups：the periodontal therapy group（group A）and the control group（groupB）. PLI,SBI, PD and GHI were measured at baseline and the following 3, 6, 12 month. Results The periodontal indexes and general conditions were no differences between two groups; During the observed periods, the gingival status of group A were continually improving（P〈0.05）, the gingival hyperplasia appeared in group A, but there was no difference among0, 3, 6, 12 month（P〉0.05）. The control group presented a significantly higher gingival index than the initial（P〈0.05）. Conclusion The periodontal infection might be one important factor of gingival hyperplasia induced by cyclosporineA,The basic periodontal therapy would have an effect on the cyclosporine A related gingival hyperplasia.