| 中药甘遂注射液的毒性试验研究 |
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| 引用本文： | 吴坤 韩向阳. 中药甘遂注射液的毒性试验研究[J]. 哈尔滨医科大学学报, 1990, 24(6): 484-486 |
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| 作者姓名： | 吴坤 韩向阳 |
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| 作者单位： | 哈尔滨医科大学公共卫生学院毒理学教研室(吴坤)，哈尔滨医科大学营养与食品卫生学教研室(陈炳卿，张桂荃，任莹)，哈尔滨医科大学一院妇产科(韩向阳)，哈尔滨医科大学一院药剂科(谷正兆) |
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| 摘 要： | 本文报道了雌性小鼠腹腔注射中药甘遂注射液,LD_(50)为88mg/kg,相当于人体实际用量的17.6倍;致突变试验为阴性结果,其中包括小鼠骨髓细胞染色体畸变分析和基因突变试验;用甘遂注射液引产后对小鼠再次受孕率无影响;在5mg/kg和1mg/kg剂量下均有明显胚胎毒性,但对存活胎仔无致畸作用。
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| 关 键 词： | 甘遂注射液 毒性试验 引产药 中药 |
Toxicological Studies on Injection of Euphorbia Kansui Liou |
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| Wu Kun et al. Toxicological Studies on Injection of Euphorbia Kansui Liou[J]. Journal of Harbin Medical University, 1990, 24(6): 484-486 |
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| Authors: | Wu Kun et al |
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| Affiliation: | Department of Toxicology |
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| Abstract: | The results of toxicological evaluation on injection of Euphorobia kansui Liou showed that it is an acute toxic drug, the LD_(50) for female mice was 88mg/kg which is 17.6 times the dose actually used by human being, Euphorbia kansui Liou has neither mutagenic action for body cells nor genotoxicity for Salmonella typhinurium strains . Also , there is no significant influence for repregnant rate of the mice that once aborted by using this injection . Under both 1 mg/kg and 5 mg/kg doses,. the absorbed rate of fetus increased while the living rate decreased for the pregnant rats, suggesting that injection of Euphorbia kansui Liou has some embryotoxicity, but no teratogenic effect was found for the survive fetus. |
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| Keywords: | Euphorbia kansui Liou Acute toxicity Mutagenicity Teratogenicity |
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