Protected environment-prophylactic antibiotic program for malignant lymphoma. Randomized trial during chemotherapy to induce remission. |
| |
Authors: | G P Bodey V Rodriguez F Cabanillas E J Freireich |
| |
Affiliation: | Houston, Texas USA |
| |
Abstract: | Fifty-eight patients with malignant lymphoma were randomly allocated to receive three courses of chemotherapy to induce remission with CHOP-Bleo on the protected environment-prophylactic antibiotic (PEPA) program (30 patients) or as controls (28 patients). The complete remission rate for all patients was 74 per cent, for patients with diffuse histiocytic lymphoma 78 per cent and for patients with nodular poorly differentiated lymphocytic lymphoma 65 per cent. There were no significant differences in response rates and duration of responses between those on the PEPA program and control patients. The frequency of infection was significantly lower among the patients on the PEPA program, and dosage escalation of the chemotherapeutic agents was accomplished more often among these patients. Dosage escalation did not increase the complete remission rate, but it did reduce the relapse rate and signficantly reduced the fatality rate. The duration of remission and survival was significantly longer for those patients who received dosage escalation. |
| |
Keywords: | Requests for reprints should be addressed to Dr. Gerald P. Bodey The University of Texas System Cancer Center Texas Medical Center Houston Texas 77030. |
本文献已被 ScienceDirect 等数据库收录! |