| PI3K-mTOR信号通路的研究进展 |
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| 引用本文： | 周虹,文富强,黄向阳. PI3K-mTOR信号通路的研究进展[J]. 国际呼吸杂志, 2008, 28(21): 1337-1340 |
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| 作者姓名： | 周虹 文富强 黄向阳 |
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| 作者单位： | 四川大学华西医院呼吸内科,成都,610041;四川大学华西医院呼吸内科,成都,610041;四川大学华西医院呼吸内科,成都,610041 |
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| 摘 要： | PI3K-mTOR(phosphoinositide-3一kinase/the mammalian target of rapamycin)信号通路在细胞的生长、分化、凋亡等方面都发挥着重要作用,文章对该通路的组成、调节、效应、抑制剂及其应用等方面作了介绍,并阐述了干扰素α通过该信号通路刺激基因表达的研究现况.
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| 关 键 词： | PI3K-mTOR 干扰素α |
Advancement of PI3K-mTOR signaling pathway |
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| ZHOU Hong,WEN Fu-qiang,HUANG Xiang-yang. Advancement of PI3K-mTOR signaling pathway[J]. International Journal of Respiration, 2008, 28(21): 1337-1340 |
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| Authors: | ZHOU Hong WEN Fu-qiang HUANG Xiang-yang |
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| Abstract: | Previous studies have demonstrated that phosphoinositide-3-kinase/tbe mammalian target of rapamycin(PI3K-mTOR) signaling pathway can be involved in a number of cellular processes including cell proliferation, differentiation, survival, and tumor growth. This review describs the recent advances in understanding the PI3K-mTOR signaling pathway, the PI3K-mTOR inhibitors, and also the regulation and the role of PI3K-mTOR pathway. Also it sheds light on investigations between interferon-alpha and PI3KmTOR pathway. |
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| Keywords: | PI3K-mTOR |
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