| 硫酸乙酰肝素蛋白聚糖与肠黏膜屏障 |
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| 引用本文： | 张绍衡,陈烨,张亚历.硫酸乙酰肝素蛋白聚糖与肠黏膜屏障[J].胃肠病学,2009,14(6):371-374. |
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| 作者姓名： | 张绍衡 陈烨 张亚历 |
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| 作者单位： | 南方医科大学南方医院消化病研究所,510515 |
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| 摘 要： | 肠黏膜屏障是肠道屏障的重要组成部分。硫酸乙酰肝素蛋白聚糖（HSPG）广泛存在于脊椎动物细胞表面，在细胞的增殖和分化、细胞间以及病原体与细胞间的黏附、信号转导、免疫应答等一系列重要生理、病理过程中发挥作用。目前已发现HSPG参与了肠黏膜屏障的构成，并与黏膜屏障功能和一些肠道疾病的发生相关。本文就HSPG与肠黏膜屏障的关系及其研究进展作一综述。
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| 关 键 词： | 类肝素硫酸蛋白聚糖 黏膜屏障 细胞黏附 肠道炎症 免疫 |
Heparan Sulfate Proteoglycan and Intestinal Mucosal Barrier |
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| ZHANG Shaoheng,CHEN Ye,ZHANG Yali.Heparan Sulfate Proteoglycan and Intestinal Mucosal Barrier[J].Chinese Journal of Gastroenterology,2009,14(6):371-374. |
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| Authors: | ZHANG Shaoheng CHEN Ye ZHANG Yali |
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| Institution: | ZHANG Shaoheng, CHEN Ye, ZHANG Yali. (Institute for Digestive Diseases, Nanfang Hospital, Southern Medical University, Guangzhou ,510515) |
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| Abstract: | Intestinal mucosal barrier is a critical component of the intestinal barrier. Heparan sulfate proteoglycan （HSPG）, which is widely distributed on the surface of vertebrate cells, has diverse biological effects on cell proliferation and differentiation, cell-cell and cell-pathogen adhesion, signal transduction, immune response and other physiological and pathological processes. It has been demonstrated that HSPG is implicated in the construction of intestinal mucosal barrier, and is correlated with the function of mucosal barrier and pathogenesis of some intestinal diseases. This review focused on the relationship between HSPG and intestinal mucosal barrier and its new advances. |
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| Keywords: | Heparan Sulfate Proteoglycan Mucosal Barrier Cell Adhesion Intestinal Inflammation Immunity |
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