黄连素对精神分裂症患者血脂水平影响的Meta分析

目的系统评价黄连素对精神分裂症患者血脂水平的影响,为精神分裂症患者血脂干预方案的选择提供参考。方法系统检索英文数据库(PubMed、PsycINFO、Embase、Cochrane Library)和中文数据库(中国期刊全文数据库、万方数据库),纳入关于黄连素对精神分裂症患者血脂水平影响的随机对照研究(RCT)。由两位研究者独立进行文献筛选、数据提取和方法学质量评价,采用RevMan 5.3进行Meta分析。结果共纳入3篇RCT,包括207例精神分裂症患者,其中黄连素组103例,对照组104例。Meta分析结果显示,黄连素组的甘油三脂水平低于对照组(WMD=-0.54,95%CI:-0.75～-0.33),差异有统计学意义(P0.01);黄连素组胆固醇水平低于对照组(WMD=-0.48,95%CI:-0.67～-0.29),差异有统计学意义(P0.01);黄连素组低密度脂蛋白胆固醇水平低于对照组(WMD=-0.56,95%CI:-0.74～-0.38),差异有统计学意义(P0.01);黄连素组高密度脂蛋白胆固醇水平高于对照组(WMD=0.06,95%CI:0.02～0.10),差异有统计学意义(P0.01)。结论黄连素联合抗精神病药物可改善精神分裂症患者的血脂水平,调控脂肪代谢。

Effect of adjunctive berberine on blood lipids in patients with schizophrenia:a Meta - analysis

Objective To systematically evaluate the effect of berberine on blood lipids levels in patients with schizophrenia,so as to provide references for the intervention program of blood lipid in patients with schizophrenia. Methods Randomized controlled clinical trials ( RCTs ) in English databases ( PubMed, PsycINFO, Embase, Cochrane library) and Chinese databases ( CNKI, Wanfang) were retrieved. The literature screening, data extraction and quality assessment were independently completed by two researchers. RevMan 5. 3 was used for Meta - analysis. Results A total of 3 RCTs ( n = 207) were included, including 103 patients in the berberine group and 104 patients in the control group. Meta - analysis showed that the blood triglyceride level in the berberine group was lower than that in the control group ( WMD = - 0. 54, 95% CI: - 0. 75 ~ - 0. 33) , with statistic difference( P < 0. 01 ) .The cholesterol level of the berberine group was lower than that of the control group ( WMD = - 0. 48, 95% CI: - 0. 67 ~ - 0. 29) ,with statistic difference ( P < 0. 01 ) . The low - density lipoprotein cholesterol level of the berberine group was lower than the control group ( WMD = - 0. 56, 95% CI: - 0. 74 ~ - 0. 38) , with statistic difference ( P < 0. 01 ) . The high - density lipoprotein cholesterol level in the berberine group was higher than that in the control group ( WMD = 0. 06, 95% CI: 0. 02 ~ 0. 10) , with statistic difference ( P < 0. 01 ) . Conclusion The application of berberine combined with antipsychotic drugs can effectively ameliorate the blood lipids levels as well as regulate fat metabolism in patients with schizophrenia.