家庭干预辅助碳酸锂治疗康复期双相情感障碍的效果

目的 探讨家庭干预辅助碳酸锂治疗康复期双相情感障碍的效果，为提高治疗效果提供参考。 方法 选取2018年1月-12月在佛山市第三人民医院住院治疗出院后2个月、符合《精神障碍诊断与统计手册（第5版）》（DSM-5）双相情感障碍诊断标准、病情稳定且持续服用碳酸锂治疗的患者68例，采用随机数字表法分为研究组和对照组各34例，两组均接受碳酸锂治疗，研究组采用家庭干预辅助碳酸锂治疗，两组均治疗4个月，其中家庭干预每两周一次。于干预前后采用焦虑自评量表(SAS)和抑郁自评量表(SDS)评定患者的焦虑和抑郁症状，干预后采用世界卫生组织生存质量测定简表（WHOQOL-BREF）评定患者的生活质量。 结果 干预后研究组SAS、SDS总评分低于对照组[（47.21±2.79）分vs.（52.79±2.42）分，（53.32±2.43）分vs.（56.41±3.49）分，t=8.813、4.231，P均<0.01]。研究组WHOQOL-BREF的生理、心理、社会关系领域评分以及总评分均高于对照组，差异有统计学意义[（5.62±0.63）分vs.（4.29±0.35）分，（12.42±4.24）分vs.（5.38±1.34）分，（3.46±0.34）分vs.（1.38±0.53）分，（39.14±11.21）分vs.（29.19±4.42）分，t=4.815~19.260，P均<0.01]。 结论 家庭干预辅助碳酸锂治疗康复期双相情感障碍患者的效果可能优于单用碳酸锂治疗，其生活质量更高。

Effect of family intervention assisted lithium carbonate in the treatment of convalescent bipolar disorder

Objective To explore the efficacy of family intervention assisted lithium carbonate in the treatment of bipolar disorder patients at convalescent phase, and to provide references for related treatment. Methods Based on diagnostic criteria of Diagnostic and Statistical Manual of Mental Disorders, fifth edition (DSM-5), a total of 68 bipolar disorder patients with stable condition and continuous lithium carbonate treatment who were hospitalized in Third People''s Hospital of Foshan from January to December 2018 and discharged for two months were enrolled. The selected individuals were divided into control group and study group according to the random number table method, 34 cases each. Both groups received lithium carbonate treatment, based on this, the study group applied family intervention once every two weeks; treatments in both groups lasted for 4 months. Then the anxiety and depression symptoms, as well as the quality of life of patients were assessed by Self-rating Anxiety Scale (SAS), Self-rating Depression Scale (SDS), and the World Health Organization Quality of Life-Brief Version (WHOQOL-BREF). Results After intervention, the total scores of SAS and SDS in the study group were lower than those in the control group [(47.21±2.79) vs. (52.79±2.42), (53.32±2.43) vs. (56.41±3.49), t=8.813, 4.231, P<0.01]. The scores of physiological field, psychological field, social relations and the total scores of WHOQOL-BREF in the study group were all higher than those in the control group [(5.62±0.63) vs. (4.29±0.35), (12.42±4.24) vs. (5.38±1.34), (3.46±0.34) vs. (1.38±0.53), (39.14±11.21) vs. (29.19±4.42), t=4.815~19.260, P<0.01]. Conclusion Compared with lithium carbonate treatment, its combination with family intervention for bipolar disorder patients at convalescent phase has better clinical efficacy, and the quality of life of patients is also better.