157例妊娠梅毒孕妇规范治疗后新生儿血清学追踪观察

目的:观察妊娠梅毒孕妇经过规范治疗后新生儿血清学情况。方法:分析2012年1月至2016年6月我院产前门诊及各区县保健站妊娠梅毒孕妇及所生新生儿的梅毒感染情况。结果:157例新生儿中,TRUST和TPPA同时阳性40例(25.5%), TPPA单阳性者106例(67.5%)。母亲TRUST及TPPA双阳性时,新生儿TRUST阳性40例, TPPA阳性为105例,均高于母亲TPPA单阳性时的新生儿比例。40例TRUST及TPPA双阳性的新生儿中,39例(97.5%)于出生后6个月TRUST转阴,转阴高峰在出生后3个月(32例,80.0%);8例(20.0%)于出生后6个月TPPA转阴,25例(62.5%)于出生后9个月转阴,12个月全部转阴。106例TPPA单阳性新生儿中,13例(12.3%)TPPA于出生后6个月转阴,75例(70.7%)于出生后9个月转阴,12个月全部转阴。所有随访的新生儿无一例出现先天梅毒。结论:妊娠梅毒孕妇规范治疗后能够明显降低先天梅毒感染率。

Serological follow-up of newborns after standardized treatment of 157 pregnant women with pregnant syphilis

Objective:To evaluate the serological changes in newborns after standardized treatment of pregnant women with syphilis.Methods:Syphilis infection was retrospectively analyzed in pregnant women and newborns in the prenatal clinics from January 2012 to June 2016.Results:In 157 newborns,40 cases(25.5%)showed both TRUST and TPPA positive,and 106 cases(67.5%)were only TPPA positive.In newborns whose mothers were positive for both TRUST and TPPA,40 newborns were positive for both TRUST and TPPA,and 105 newborns were TPPA positive,which both were higher than that whose mothers were only TPPA positive.In those 40 newborns with both TRUST and TPPA positive,TRUST and TPPA became negative in 39(97.5%)and 8(20.0%)cases,respectively,within six months.Thirty two out of these 40 newborns(80.0%)became negative for TRUST within 3 months,while 25(62.5%)were TPPA negative within 9 months.TPPA was negative in all 40 cases within 12 months after birth.Of 106 newborns with only TPPA positive,13(12.3%)cases became TPPA negative within 6 months,and 75(70.7%)cases were TPPA negative within 9 months after birth.Within 12 months after birth,all cases were TPPA negative.No neonate developed congenital syphilis during the follow-up period.Conclusion:Standardized treatment of pregnant women with syphilis can significantly reduce the risk of congenital syphilis.