| 甘氨酸对脂多糖诱导LBPmRNA表达的影响 |
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| 引用本文： | 单于,陆大祥,王华东,戚仁斌,付咏梅,李晓娟,李楚杰. 甘氨酸对脂多糖诱导LBPmRNA表达的影响[J]. 中国病理生理杂志, 2003, 19(7): 920-922 |
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| 作者姓名： | 单于 陆大祥 王华东 戚仁斌 付咏梅 李晓娟 李楚杰 |
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| 作者单位： | 暨南大学医学院病理生理学教研室, 广东 广州 510632 |
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| 基金项目： | 国家自然科学基金资助项目(No.39870360);广东省自然科学基金项目资助项目(No.980706) |
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| 摘 要： | 目的:了解甘氨酸(GLY)对脂多糖(LPS)诱导脂多糖结合蛋白(LBP)mRNA表达的影响。方法:用RT-PCR方法检测LPS作用下大鼠肝组织LBPmRNA的表达水平,并在此基础上观察甘氨酸对LPS诱导大鼠肝组织LBPmRNA表达的影响。结果:LPS组大鼠肝组织LBPmRNA表达高于control组(P＜0.01),GLY+LPS组大鼠肝组织LBPmRNA表达低于LPS组(P＜0.01)。结论:LPS可诱导大鼠肝组织LBPmRNA的表达,甘氨酸能抑制LPS诱导大鼠肝组织LBPmRNA的表达。
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| 关 键 词： | 甘氨酸 脂多糖类 脂多糖结合蛋白 |
| 文章编号： | 1000-4718(2003)07-0920-03 |
| 收稿时间： | 2003-05-13 |
| 修稿时间： | 2003-05-13 |
Influence of glycine on LBP mRNA expression induced by LPS in the liver of rats |
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| SHAN Yu,LU Da-xiang,WANG Hua-dong,QI Ren-bin,FU Yong-mei,LI Xiao-juan,LI Chu-jie. Influence of glycine on LBP mRNA expression induced by LPS in the liver of rats[J]. Chinese Journal of Pathophysiology, 2003, 19(7): 920-922 |
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| Authors: | SHAN Yu LU Da-xiang WANG Hua-dong QI Ren-bin FU Yong-mei LI Xiao-juan LI Chu-jie |
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| Affiliation: | Department of Pathophysiology, Medical College of Jinan University, Guangzhou 510632, China |
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| Abstract: | AIM: To study the influence of glycine(GLY) on lipopolysaccharide-binding protein(LBP) mRNA expression induced by LPS. METHODS: The level of LBP mRNA expression in liver tissues of rats was examined by RT-PCR,and the effects of glycine on LBP mRNA expression in liver tissues of rats induced by LPS were investigated. RESULTS: The level of LBP mRNA expression in hepatic tissue of rats in the LPS group was significantly higher than that in the control group( P< 0.01),the level of LBP mRNA expression in the hepatic tissue of rats in the LPS+GLY group was lower than that in the LPS group( P< 0.01). CONCLUSION: LPS can induce LBP mRNA expression in the hepatic tissue of rats, glycine can inhibit LBP mRNA expression in the hepatic tissue of rats treated by LPS. |
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| Keywords: | Glycine Lipopolysaccharides Lipopolysaccharide binding protein |
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