mar Operon involved in multidrug resistance of Enterobacter aerogenes |
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| Authors: | Chollet Renaud Bollet Claude Chevalier Jacqueline Malléa Monique Pagès Jean-Marie Davin-Regli Anne |
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| Affiliation: | Enveloppe Bactérienne, Antibiotiques et Colonisation, CJF 9606-EA 2197, Facultés de Médecine et Pharmacie, Université de la Méditerranée, 13385 Marseille Cedex 05, France. |
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| Abstract: | We determined the sequence of the entire marRAB operon in Enterobacter aerogenes. It is functionally and structurally analogous to the Escherichia coli operon. The overexpression of E. aerogenes MarA induces a multidrug resistance phenotype in a susceptible strain, demonstrated by a noticeable resistance to various antibiotics, a decrease in immunodetected porins, and active efflux of norfloxacin. |
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