| 基于Excel函数求解血管外给药二室模型的药动学及隔室模型参数 |
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| 引用本文： | 袁进,石磊,赵树进. 基于Excel函数求解血管外给药二室模型的药动学及隔室模型参数[J]. 中国药房, 2008, 19(2): 106-108 |
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| 作者姓名： | 袁进 石磊 赵树进 |
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| 作者单位： | 广州军区广州总医院药剂科,广州市,510010 |
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| 摘 要： | 目的:建立以Excel函数求解血管外给药二室模型的药动学及隔室模型参数的方法。方法:采用残数法,利用Excel函数,逐步求解药动学和隔室模型参数。结果:基于Excel函数可直观演示血管外给药二室模型的药动学及隔室模型参数计算过程,结果与教材一致。结论:本方法操作简便、界面直观、结果可靠、易于推广,可用于临床教学或实验中药动学参数的计算。
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| 关 键 词： | Excel 残数法 血管外给药二室模型 药动学 隔室模型 参数 |
| 文章编号： | 1001-0408(2008)02-0106-03 |
| 修稿时间： | 2007-07-07 |
Calculation of Pharmacokinetic Parameters and Two-Compartment Model''''s Parameters by Extravascular Administration Based on Excel Function |
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| YUAN Jin,SHI Lei,ZHAO Shu-jin. Calculation of Pharmacokinetic Parameters and Two-Compartment Model''''s Parameters by Extravascular Administration Based on Excel Function[J]. China Pharmacy, 2008, 19(2): 106-108 |
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| Authors: | YUAN Jin SHI Lei ZHAO Shu-jin |
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| Affiliation: | (Dept. of Pharmacy, Guangzhou General Hospital of Guangzhou Military Command, Guangzhou 510010, China) |
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| Abstract: | OBJECTIVE:To calculate pharmacokinetic parameters and compartment model's parameters by extravascular administration based on Excel function.METHODS:The parameters of pharmacokinetics and compartment model were calculated using residual method and Excel function.RESULTS:Excel can be used to directly demonstrate calculation process of parameters of pharmacokinetics and compartment model,with calculation results in line with those stated in textbooks.CONC-LUSION:The established method is simple,direct-viewing,reliable and easy to be extended,and it can be used to calculate pharmacokinetic parameters in clinical teaching or experiments. |
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| Keywords: | Excel Residual method Two compartment model by extravascular administration Pharmacokinetics Compartment model Parameter |
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