Pioglitazone and Losartan Modify Hemodynamic and Metabolic Parameters and Vascular Prostanoids in Fructose-Overloaded Rats |
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| Authors: | H.A. Peredo M.A. Mayer A. Carranza A.M. Puyó |
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| Affiliation: | 1. Cátedras de Anatomía Humana (Macro y Microscópica) y Farmacotecnia I, Facultad de Farmacia y Bioquímica, Instituto de Morfología JJ Naón, Primera Cátedra de Anatomía, Facultad de Medicina, INFIBIOC, Universidad de Buenos Aires and CONICET, Argentinahoracio.peredo@gmail.com;3. Cátedras de Anatomía Humana (Macro y Microscópica) y Farmacotecnia I, Facultad de Farmacia y Bioquímica, Instituto de Morfología JJ Naón, Primera Cátedra de Anatomía, Facultad de Medicina, INFIBIOC, Universidad de Buenos Aires and CONICET, Argentina |
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| Abstract: | This study analyzes the effects of losartan (AT1 blocker) and pioglitazone (insulin sensitizer), alone and in combination, in the fructose-overloaded rat, a model of metabolic syndrome. All treatments (nine weeks) reduced blood pressure and triglyceridemia and also restored the diminished release of vasodilator prostaglandins (prostacyclin in aorta and mesenteric vascular bed and prostaglandin E2 in the latter). Pioglitazone, alone and in combination with losartan, reduced the release of the vasoconstrictor thromboxane in controls and fructose rats in both vascular preparations. In conclusion, although combination therapy and single treatments exerted similar effects, there may still be some advantage to the combined treatment. |
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| Keywords: | pioglitazone losartan fructose prostanoids hypertension triglycerides |
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