Effect of Sex Hormones on Non-Esterified Fatty Acids,Intra-Abdominal Fat Accumulation,and Hypertension Induced by Sucrose Diet in Male Rats |
| |
Authors: | Mohammed El Hafidi Israel Pérez Silvia Carrillo Guillermo Cardoso José Zamora Roberto Chavira |
| |
Affiliation: | 1. Department of Biochemistry, Instituto Nacional de Cardiología “Ignacio Chavez,”, Juan Badiano 1, Sección XVI, Tlalpan, Mexicoelhafidi@mail.ssa.gob.mx;3. Department of Pathology, Instituto Nacional de Cardiología “Ignacio Chavez,”, Juan Badiano 1, Sección XVI, Tlalpan, Mexico;4. Department of Biochemistry, Instituto Nacional de Cardiología “Ignacio Chavez,”, Juan Badiano 1, Sección XVI, Tlalpan, Mexico;5. Department of Endocrinology, Instituto Nacional de Cardiología “Ignacio Chávez,”, Juan Badiano 1, Sección XVI, Tlalpan, Mexico;6. Department of Reproduction Biology, Instituto Nacional de la Nutrición “Salvador Zubirán,”, Tlalpan, Mexico |
| |
Abstract: | Sucrose-fed rats () had higher intra-abdominal fat mass and plasma non-esterified fatty acids and lower testosterone levels, () were hypertensive, and () had lower plasma NO metabolites than controls. The lack of testosterone by castration of sucrose-fed rats decreased high blood pressure and circulating non-esterified fatty acids and increased NO metabolites. The administration of testosterone to castrated sucrose-fed rats restored hypertension, fat accumulation, and high-circulating non-esterified fatty acids, and lowered NO metabolite levels whereas estradiol treatment did not significantly affect these variables in castrated animals. This study proposes that the low levels of testosterone found in sucrose-fed rats are sufficient to maintain central obesity and increased circulating non-esterified fatty acids, which contribute to the development of hypertension in sucrose-fed rats by modulating the biosynthesis of NO. |
| |
Keywords: | hypertension NEFA NO obesity sex hormones sucrose diet |
|
|