七氟烷、异氟烷和恩氟烷在肝癌切除术中的应用

目的观察七氟烷、异氟烷和恩氟烷全麻对肝癌切除术患者的影响。方法将80例ASAⅠ~Ⅱ级择期行肝癌切除术的病人随机分为四组:七氟烷组(S1组)、异氟烷组(S2组)、恩氟烷组(S3组)和对照丙泊酚组(P组),每组20例。S1、S2、S3组分别行七氟烷、异氟烷和恩氟烷吸入麻醉,P组行丙泊酚静脉麻醉。观察四组患者麻醉前(基础值)、诱导后、插管后1 min、5 min、10min、切皮时、切皮后30 min、60 min、停药时、术毕、苏醒时、拔管时、拔管后1 min、5 min、10 min的MAP、HR。术后1 d、5 d、10 d、20d抽取病人静脉血,测定谷丙转氨酶(ALT)、谷草转氨酶(AST)水平。结果与基础值相比,四组在手术过程中,MAP、HR都有波动,但各组之间MAP无显著性差异(P>0.05),S2组HR较其他三组升高(P<0.05),但总体变化范围未超过±30%;与术前相比,术后四组患者的ALT、AST水平均有显著性差异(P<0.05或0.01),但各组相同时间点的ALT、AST水平均无显著性差异(P>0.05)。结论七氟烷、异氟烷和恩氟烷应用于肝癌切除术麻醉,效果满意。

The application of sevoflurane,isoflurane and enflurane in liver carcinoma hepatectomy

Objective To observe the effect of sevoflurane,isoflurane and enflurane in treating patients with liver carcinoma hepatectomy.Methods Eighty ASA Ⅰor Ⅱ patients undergoing elective liver carcinoma hepatectomy under general anesthesia were randomly allocated to one of four groups with 20 patients in each group:group S1,gave sevoflurane inhalation anesthesia;group S2,isoflurane;group S3,enflurane;group P,gave intravenous anesthesia of propofol.Observed the MAP、HR in all groups before hocus(baise values),after inducement,1 min、5 min、10 min after trachea cannula and some other corresponding timepionts.The serum glutamic-pyruvic transaminase and glutamic-oxalacetic transaminase level were detected 1 d、5 d、10 d、20 d after the operation in all patients.Results There was no significant difference between the four groups on MAP(P>0.05).Compared with that before the operation,there was significant difference in all four groups on serum ALT、AST level(P<0.05 or 0.01),but there was no significant difference between the four groups(P>0.05).Conclusion Sevoflurane,isoflurane and enflurane could be great help in liver carcinoma hepatectomy.