| 人尿苷二磷酸葡萄糖醛酸转移酶基因多态性与相关疾病易感性 |
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| 引用本文： | 谷雨,李燕. 人尿苷二磷酸葡萄糖醛酸转移酶基因多态性与相关疾病易感性[J]. 国际药学研究杂志, 2008, 35(2): 107-110 |
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| 作者姓名： | 谷雨 李燕 |
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| 作者单位： | 中国医学科学院/中国协和医科大学药物研究所,北京,100050;中国医学科学院/中国协和医科大学药物研究所,北京,100050 |
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| 摘 要： | 尿苷二磷酸葡萄糖醛酸转移酶（UGT）是体内重要的药物代谢Ⅱ相酶，具有明显的基因多态性。评价基因多态性对疾病易感性影响的重要性，建立基因多态性数据库并进行致病基因 疾病易感性的种群研究具有深远意义。本文拟就人UGT基因多态性及相关疾病易感性进行简述。
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| 关 键 词： | 尿苷二磷酸葡萄糖醛酸转移酶 基因多态性 疾病易感性 |
| 收稿时间： | 2007-10-17 |
Genetic polymorphism in UDP-glucuronosyltransferase and disease susceptibility |
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| GU Yu,LI Yan. Genetic polymorphism in UDP-glucuronosyltransferase and disease susceptibility[J]. Foreign Medical Sciences(Section of Pharmarcy), 2008, 35(2): 107-110 |
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| Authors: | GU Yu LI Yan |
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| Affiliation: | （Institute of Materia Medica,Chinese Academy of Medical Sciences &; Peking Union Medical College, Beijing 100050, China） |
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| Abstract: | Uridine diphosphate(UDP)-glucuronosyltransferase is one of the most important phase Ⅱ drug metabolizing enzymes in human, and some of them are identified as genetic polymorphism. Evaluating the genetic polymorphism′s effects on susceptibility of disease, setting up data base for genetic polymorphism and studying on the relationship between virulence gene and susceptibility of disease are of significance. Herein, the genetic polymorphism in UDP-glucuronosyltransferase and the susceptibility of relative diseases are reviewed. |
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| Keywords: | UDP-glucuronosyltransferase genetic polymorphism disease susceptibility |
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