| 从血浆促肾上腺皮质素释放素样生物活性和神经递质类药物的作用探讨Cushing病病因 |
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| 引用本文： | 童伟,邝安堃,丁霆,陈家伦,许曼音,陈德志.从血浆促肾上腺皮质素释放素样生物活性和神经递质类药物的作用探讨Cushing病病因[J].中华内分泌代谢杂志,1992(2). |
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| 作者姓名： | 童伟 邝安堃 丁霆 陈家伦 许曼音 陈德志 |
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| 作者单位： | 上海市内分泌研究所，上海市内分泌研究所，上海市内分泌研究所，上海市内分泌研究所，上海第二医科大学附属瑞金医院，上海第二医科大学附属瑞金医院 200025，200025，200025，200025，进修医师 |
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| 摘 要： | 用大鼠垂体细胞灌流技术和ACTH直接法放射免疫测定研究了正常人、Cushing病患者和其他下丘脑-垂体-肾上腺轴疾病患者血浆中的促肾上腺皮质素释放素样生物活性,结合Cushing病患者对神经递质类药物的反应所作观察提出如下假设:绝大多数Cushing病原发于垂体,在发病过程中,高皮质醇血症损害海马,削弱其对下丘脑-垂体-肾上腺轴的抑制作用是一个重要环节。
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| 关 键 词： | Cushing病 神经递质类药物 促肾上腺皮质素释放素样生物活性 |
STUDY ON THE ETIOLOGY OF CUSHING'S DISEASE BASED ON PLASMA CORTICOTROPHIN-RELEASING HORMONE-LIKE BIOACTIVITY AND EFFECTS OF NEUROTRANSMITTERS |
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| Tong Wei,et al..STUDY ON THE ETIOLOGY OF CUSHING'S DISEASE BASED ON PLASMA CORTICOTROPHIN-RELEASING HORMONE-LIKE BIOACTIVITY AND EFFECTS OF NEUROTRANSMITTERS[J].Chinese Journal of Endocrinology and Metabolism,1992(2). |
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| Authors: | Tong Wei |
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| Institution: | Tong Wei,et al.
Shanghai Research Institute of Endocrinology,Shanghai 200025 |
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| Abstract: | The plasma corticotrophin-releasing hormone-like bioactivity was measured in normal individuals, patients with Cushing's disease and other diseases of hypothalamic-pituitary-adrenal axis with the techniques of rat pituitary cell peri-tusion and AGTH radioimmunoassay. Combined with the response of the patients to neurotransmitter agonist and antagonist, it was hypothesized that most patients with Cushing's disease have a primary pituitary lesion and that hyper-tisolemia damaging hippocampus and weakening its inhibition on hypothalamic-pituitary-adrenal axis may have an important role in the pathogenesis. |
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| Keywords: | Cushing's disease Neurotransmitter CRH bioactivity |
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