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结核性脑膜炎患者预后相关因素分析
引用本文:罗永坚,蔺心敬,李吕力,李燕华,周礼园.结核性脑膜炎患者预后相关因素分析[J].中国临床医学,2009,16(5):696-698.
作者姓名:罗永坚  蔺心敬  李吕力  李燕华  周礼园
作者单位:广西壮族自治区人民医院神经内科,广西南宁,530021
摘    要:目的:分析结核性脑膜炎患者预后的相关因素。方法:回顾分析1991年1月-2003年12月123例确诊结核性脑膜炎住院患者的临床资料。采用电话、门诊等随访,改良Rankin评分为结局指标,最终101例患者纳入分析。对影响预后因素进行单因素和有序多分类累积回归分析。结果:101例患者中,随访时间最短12d,最长22个月,失访9例(8.9%)。单因素及有序多分类累积回归分析显示,预后不良与Glasgow Scale(GCS)评分低(OR:0.757,95%CI:0.632~0.908,P=0.003),有肢体瘫痪(OR:0.317,95%CI:0.109~0.922,P=0.035),异烟肼(INH)用量小(OR:0.113,95%CI:0.019~0.664,P=0.016),联合治疗方案未用吡嗪酰胺(OR:3.386,95%CI:1.480~7.747,P=0.004)、激素(OR:3.383,95%CI:1.507~7.592,P=0.003)及鞘内注射(OR:8.782,95%CI:3.025~25.496,P=0.000)有关,其中鞘内注射和吡嗪酰胺对预后不良的影响最大。结论:GCS评分低,有瘫痪,异烟肼用量小,未用吡嗪酰胺,激素和鞘内注射是预后不良的主要影响因素。

关 键 词:脑膜炎  结核  预后

A Analysis of Prognosis and Influential Factors of Tuberculous Meningitis
LUO Yongjian,LIN Xinjing,LI Luli,LI Yanhua,ZHOU Liyuan.A Analysis of Prognosis and Influential Factors of Tuberculous Meningitis[J].Chinese Journal Of Clinical Medicine,2009,16(5):696-698.
Authors:LUO Yongjian  LIN Xinjing  LI Luli  LI Yanhua  ZHOU Liyuan
Institution:LUO Yongjian LIN Xinjing LI Luli LI Yanhua ZHOU Liyuan Department of Neurology,Autonomous Regions Hospital of Guangxi,Nanning 530021
Abstract:Objective:to observe the prognosis and to analyze the influential factors of tuberculous meningitis patients. Methods: 123 tuberculous meningitis cases were retrospectively from January 1991 to December 2003.The patients were followed up through phone or clinic and the modified Rankin scale (MRS)score was used as the index of primary outcome. The influential factors were analyzed by monovariate and multivariate ordinal Regression(cumulative logistic)analysis. Results: the shortest follow-up time was 12 day ...
Keywords:Meningitis  Tubercular  Prognosis  
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