黄果茄中1个新的黄酮类化合物

目的研究黄果茄Solanum virginianum的化学成分。方法通过硅胶柱色谱、Sephadex LH-20柱色谱及高效制备薄层对黄果茄中的化学成分进行分离纯化,根据理化性质和波谱数据对其化学结构进行阐明。结果从黄果茄中发现并鉴定12个化合物,分别为5-羟基-8-甲氧基-6,7-亚甲二氧基黄酮(1)、7-羟基-6-甲氧基香豆素(2)、秦皮素(3)、5-羟基-6,7,3′,4′-四甲氧基黄酮(4)、5-羟基-4′,6,7-三甲氧基黄酮(5)、二氢阿魏酰酪胺(6)、反式-N-对羟基香豆酰酪胺(7)、5,3′-二羟基-6,7,4′-三甲氧基黄酮(8)、N-[2-(3,4-二羟基苯基)-2-羟乙基]-3-(4-甲氧基苯基)丙-2-烯酰胺(9)、N-反式香豆酰基章鱼胺(10)、5,7,4′-三羟基-6-甲氧基黄酮(11)、5,7,4′-三羟基-8-甲氧基黄酮(12)。结论化合物1为新化合物,命名为黄果茄酮;化合物2～12为首次从黄果茄中分离得到。

A new flavonoid isolated from fruits of Solanum virginianum

Objective To study the chemical constituents from the fruits of Solanum virginianum. Methods By means of preparative HPTLC and column chromatography over silica gel and Sephadex LH-20, compounds were isolated and purified. Their structures were elucidated by physico-chemical properties and spectral analyses. Results Twelve compounds were obtained and identified as:5-hydroxy-8-methoxy-6,7-methylenedioxyflavone (1), 7-hydroxy-6-methoxy coumarin (2), fraxetin (3), 5-hydroxy- 6,7,3'',4''-tetramethoxyflavone (4), 5-hydroxy-4'',6,7-trimethoxyflavone (5), dihydro-N-feruloyltyramine (6), N-trans-coumaroyltyramine (7), 5,3''-dihydroxy-6,7,4''-tritermethoxyflavone (8), N-[2-(3,4-dihydroxyphenyl)-2-hydroxyethyl]-3-(4-methoxyphenyl)-prop-2-enamide (9), N-trans-coumaroyloctopamine (10), 5,7,4''-trihydroxy-6-methoxyflavone (11), and 5,7,4''-trihydroxy-8-methoxyflavone (12). Conclusion Compound 1 is a new flavonoid, named as solacarpumon, and compounds 2-12 are isolated from Solanum virginianum for the first time.