Regulatory T Cells in Immunologic Self-Tolerance and Autoimmune Disease |
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Authors: | Shimon Sakaguchi Noriko Sakaguchi |
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Affiliation: | Department of Experimental Pathology, Institute for Frontier Medical Sciences, Kyoto University, Kyoto, Japan, and Core Research for Evolutional Science and Technology (CREST),Science and Technology Agency of Japan, Kawaguchi, Japan |
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Abstract: | Naturally arising CD25+CD4+ regulatory T cells play key roles in the maintenance of immunologic self-tolerance and negative control of various immune responses. The majority, if not all, of them are produced by the normal thymus as a functionally distinct T-cell subpopulation, and their generation is in part developmentally controlled. Genetic abnormality in the development and function of this population can indeed be a cause of autoimmune disease, immunopathology, and allergy in humans. This regulatory population can be exploited to prevent and treat autoimmune disease by strengthening and reestablishing immunologic self-tolerance. |
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Keywords: | CD25 Foxp3 immunoregulation immunologic self-tolerance IPEX regulatory T cells |
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